CAJ | 학술논문

目的探讨颅内基底神经节区生殖细胞瘤的早期诊断及综合治疗.方法对25例颅内基底神经节区生殖细胞瘤患者的年龄、性别、发病早期的临床症状、体征、血液中肿瘤标记物的榆查及影像学检查的结果等特点进行分析判断,得出早期诊断的依据并行早期综合治疗.结果 3例开颅手术,1例活榆,病理证实为生殖细胞瘤,21例通过临床特点分析,在生殖细胞瘤早期即明确诊断,末行手术,直接进行化、放疗.患者随访最长7年,最短10个月,平均45个月.1例外院手术大部分切除肿瘤,病理诊断生殖细胞瘤,来我院行化、放疗,6年后肿瘤复发,再次化疗,肿瘤消失,已随访1年未见复发,其余24例随访均未见肿瘤复发.患者经过治疗后,肿瘤虽已消失,但症状、体征并不能完全缓解.结论通过细致的临床观察,综合分析判断临床特点,基底神经节区生贿细胞瘤是可以做到早期诊断,并通过化、放疗等非手术治疗达到满意的治疗效果.
목적 탐토로내기저신경절구생식세포류적조기진단급종합치료.방법 대25례로내기저신경절구생식세포류환자적년령、성별、발병조기적림상증상、체정、혈액중종류표기물적유사급영상학검사적결과등특점진행분석판단,득출조기진단적의거병행조기종합치료.결과 3례개로수술,1례활유,병리증실위생식세포류,21례통과림상특점분석,재생식세포류조기즉명학진단,말행수술,직접진행화、방료.환자수방최장7년,최단10개월,평균45개월.1예외원수술대부분절제종류,병리진단생식세포류,래아원행화、방료,6년후종류복발,재차화료,종류소실,이수방1년미견복발,기여24례수방균미견종류복발.환자경과치료후,종류수이소실,단증상、체정병불능완전완해.결론 통과세치적림상관찰,종합분석판단림상특점,기저신경절구생회세포류시가이주도조기진단,병통과화、방료등비수술치료체도만의적치료효과.
Objective To study the early diagnosis and combined treatment with chemotherapy and radiotherapy in intracranial basal ganglia germinoma. Method To analyze and judge the characteristics of age, sex, early clinical symptoms, systems, serology and photocopy (MRI, CT) of 25 patients with intracranial basal ganglia germinoma in order to get evidences of intracranial basal ganglia germinoma for early combined treatment. Results 4 cases were diagnosed as germinoma by pathology. The other 21 cases have been diagnosed early by analyzing and judging the characteristics of age, sex, early clinical symptoms, systems, serology and photocopy (MRI, CT). All cases were treated with chemotherapy and radiotherapy. All patients were followed-up for a period from 10 months to 7 years, with the average follow-up of 45 months. The tumor recurrence was not found. Conclusions The intracranial basal ganglia germinoma can be diagnosed earlier by careful clinical observation and comprehensive analysis and judgement, and satisfied results euuld be realized with the chemotherapy and radiotherapy.