CAJ | 학술논문

将150例乙型肝炎患者随机分为5组,分别取异甘草酸镁100、150、200、250、300 mg加入10%葡萄糖注射液250 ml中静脉滴注,每日1次;均不用其他影响氨基转移酶及胆红素的药物,疗程为2周.各组均于治疗前及治疗后的2周检查ALT、AST和血清胆红素.治疗2周后,150 mg及以上治疗组的临床有效率高于100 mg治疗组,而150～300 mg治疗组间临床疗效差异无统计学意义.各组均未发现明显的不良反应.说明150 mg为异甘草酸镁治疗乙型肝炎的最佳剂量.
장150례을형간염환자수궤분위5조,분별취이감초산미100、150、200、250、300 mg가입10%포도당주사액250 ml중정맥적주,매일1차;균불용기타영향안기전이매급담홍소적약물,료정위2주.각조균우치료전급치료후적2주검사ALT、AST화혈청담홍소.치료2주후,150 mg급이상치료조적림상유효솔고우100 mg치료조,이150～300 mg치료조간림상료효차이무통계학의의.각조균미발현명현적불량반응.설명150 mg위이감초산미치료을형간염적최가제량.
Am investigation was done to identify the best and safe dosage of magnesium isoglycurrhizinate in treating hepatitis B.All 1 50 cases suffering from hepatitis B were randomly divided into five groups as A,B,C,D,E.Cases in group A were treated with magnesium isoglycurrhizinate in 100 mg per day for two weeks sololy,and in group B,C,D,E in 150 mg,200 mg,250 mg and 300 mg respectively.The changes of symptoms,index of hepatic function,clinical effective rates and side-effects were observed from treatment beginning to the end.The results that revealed there were no different effects among groups B to E,but less therapeutic effects in group A,and no obvious side-effects in all groups,suggesting that 150 mg dosage of magnesium isoglycurrhizinate should be a safe and the best dosage for treating hepatitis B.