中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2011年
4期
50-52
,共3页
闫斌%郭金涛%刘乐喜%郭雅聪%刘远洪%李照凯
閆斌%郭金濤%劉樂喜%郭雅聰%劉遠洪%李照凱
염빈%곽금도%류악희%곽아총%류원홍%리조개
颈动脉粥样硬化%脑梗死%高敏C-反应蛋白%同型半胱氨酸
頸動脈粥樣硬化%腦梗死%高敏C-反應蛋白%同型半胱氨痠
경동맥죽양경화%뇌경사%고민C-반응단백%동형반광안산
Carotid atherosclerosis%Cerebral infarction%High sensitivity C-reactive protein%Homocysteine
目的 探讨急性脑梗死患者颈动脉粥样硬化与同型半胱氨酸(Hcy)、高敏C-反应蛋白(hs-CRP)的相关性.方法 对190例急性脑梗死患者和110例健康体检者均进行颈动脉彩超多普勒检查,测量颈动脉内中膜厚度(IMT),观察有无颈动脉斑块形成,同时进行Hcy、hs-CRP、糖化血红蛋白(HbA1c)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-c)浓度测定.结果 脑梗死组Hcy、hs-CRP水平明显高于正常对照组(健康体检者),两组浓度间比较差异有统计学意义(P<0.01);根据颈动脉有无斑块将脑梗死组分为两个亚组:有斑块组、无斑块组,脑梗死有斑块组Hcy、hs-CRP浓度明显高于脑梗死无斑块组,两组浓度间比较差异有统计学意义(P<0.01).Hcy、hs-CRP升高具有一致性.结论 Hcy、hs-CRP与急性脑梗死患者颈动脉粥样硬化的发生、发展有一定的相关性,炎症反应参与了脑梗死患者颈动脉粥样硬化的形成,且Hcy、hs-CRP之间亦有一定的相关性.
目的 探討急性腦梗死患者頸動脈粥樣硬化與同型半胱氨痠(Hcy)、高敏C-反應蛋白(hs-CRP)的相關性.方法 對190例急性腦梗死患者和110例健康體檢者均進行頸動脈綵超多普勒檢查,測量頸動脈內中膜厚度(IMT),觀察有無頸動脈斑塊形成,同時進行Hcy、hs-CRP、糖化血紅蛋白(HbA1c)、總膽固醇(TC)、低密度脂蛋白膽固醇(LDL-c)濃度測定.結果 腦梗死組Hcy、hs-CRP水平明顯高于正常對照組(健康體檢者),兩組濃度間比較差異有統計學意義(P<0.01);根據頸動脈有無斑塊將腦梗死組分為兩箇亞組:有斑塊組、無斑塊組,腦梗死有斑塊組Hcy、hs-CRP濃度明顯高于腦梗死無斑塊組,兩組濃度間比較差異有統計學意義(P<0.01).Hcy、hs-CRP升高具有一緻性.結論 Hcy、hs-CRP與急性腦梗死患者頸動脈粥樣硬化的髮生、髮展有一定的相關性,炎癥反應參與瞭腦梗死患者頸動脈粥樣硬化的形成,且Hcy、hs-CRP之間亦有一定的相關性.
목적 탐토급성뇌경사환자경동맥죽양경화여동형반광안산(Hcy)、고민C-반응단백(hs-CRP)적상관성.방법 대190례급성뇌경사환자화110례건강체검자균진행경동맥채초다보륵검사,측량경동맥내중막후도(IMT),관찰유무경동맥반괴형성,동시진행Hcy、hs-CRP、당화혈홍단백(HbA1c)、총담고순(TC)、저밀도지단백담고순(LDL-c)농도측정.결과 뇌경사조Hcy、hs-CRP수평명현고우정상대조조(건강체검자),량조농도간비교차이유통계학의의(P<0.01);근거경동맥유무반괴장뇌경사조분위량개아조:유반괴조、무반괴조,뇌경사유반괴조Hcy、hs-CRP농도명현고우뇌경사무반괴조,량조농도간비교차이유통계학의의(P<0.01).Hcy、hs-CRP승고구유일치성.결론 Hcy、hs-CRP여급성뇌경사환자경동맥죽양경화적발생、발전유일정적상관성,염증반응삼여료뇌경사환자경동맥죽양경화적형성,차Hcy、hs-CRP지간역유일정적상관성.
Objective To investigate and analyze the relationship between high sensitivity C-reactive protein (hs-CRP),homocysteine(Hcy) and carotid atherosclerosis in patients with acute cerebral infarction. Methods One hundred and ninety cases of acute cerebral infarction were assigned as experimental group and one hundred and ten healthy people as control group. The changes of carotid intimal- medial thickness (IMT) were examined by carotid duplex ultrasonography scanning. The levels of hs-CRP and Hcy were measured. Glycated hemoglobin (HbA1c),total cholesterol (TC) and low-density lipoprotein (LDL) were measured routinely. Results The levels of serum hs-CRP, plasma homocysteine were significantly increased in the experimental group compared to the control group(P<0.01). Furthermore, the levels of serum hs-CRP, plasma homocysteine were also significantly increased in the experimental group with plaques compared to the experimental group with no-plaques (P<0.01).The hs-CRP level was associated with the Hcy level. Conclusions The levels of serum hs-CRP and Hcy in acute cerebral infarction patients with carotid atherosclerosis increase significantly. Inflammatory rection brings carotid atherosclerosis in cerebral infarction.
