中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2009年
5期
9-11
,共3页
室性心律失常%冠心病%胺碘酮%美托洛尔%培哚普利
室性心律失常%冠心病%胺碘酮%美託洛爾%培哚普利
실성심률실상%관심병%알전동%미탁락이%배타보리
Ventricular arrhythmias%Coronary artery disease%Amiodarone%Metoprolol%Perindopril
目的 观察长期应用小剂量胺碘酮联合美托洛尔和培哚普利防治冠心病性室性心律失常的疗效及安全性.方法 将63例2003年3月至2007年5月入住我院治疗的伴有室性心律失常的冠心病(伴或不伴心功能不全)患者随机分为观察组(33例)和对照组(30例).在常规治疗基础上,观察组给予口服胺碘酮、培哚普利和美托洛尔治疗,对照组单用培哚普利和美托洛尔.结果 在第1、2年随访时,观察组在防治室性心律失常及改善左室射血分数(LVEF)方面均明显好于对照组(P＜0.05);观察组的再住院率及猝死方面可能也好于对照组.两组在2年的随访期间均未出现严重的不良反应.结论 长期小剂量胺碘酮联合美托洛尔和培哚普利比单用美托洛尔和培哚普利能更好地防治冠心病性室性心律失常,并有助于心衰的改善,可能还能减少再住院率和猝死率,疗效明显优于单用培哚普利和美托洛尔,且无严重不良反应发生.
目的 觀察長期應用小劑量胺碘酮聯閤美託洛爾和培哚普利防治冠心病性室性心律失常的療效及安全性.方法 將63例2003年3月至2007年5月入住我院治療的伴有室性心律失常的冠心病(伴或不伴心功能不全)患者隨機分為觀察組(33例)和對照組(30例).在常規治療基礎上,觀察組給予口服胺碘酮、培哚普利和美託洛爾治療,對照組單用培哚普利和美託洛爾.結果 在第1、2年隨訪時,觀察組在防治室性心律失常及改善左室射血分數(LVEF)方麵均明顯好于對照組(P＜0.05);觀察組的再住院率及猝死方麵可能也好于對照組.兩組在2年的隨訪期間均未齣現嚴重的不良反應.結論 長期小劑量胺碘酮聯閤美託洛爾和培哚普利比單用美託洛爾和培哚普利能更好地防治冠心病性室性心律失常,併有助于心衰的改善,可能還能減少再住院率和猝死率,療效明顯優于單用培哚普利和美託洛爾,且無嚴重不良反應髮生.
목적 관찰장기응용소제량알전동연합미탁락이화배타보리방치관심병성실성심률실상적료효급안전성.방법 장63례2003년3월지2007년5월입주아원치료적반유실성심률실상적관심병(반혹불반심공능불전)환자수궤분위관찰조(33례)화대조조(30례).재상규치료기출상,관찰조급여구복알전동、배타보리화미탁락이치료,대조조단용배타보리화미탁락이.결과 재제1、2년수방시,관찰조재방치실성심률실상급개선좌실사혈분수(LVEF)방면균명현호우대조조(P＜0.05);관찰조적재주원솔급졸사방면가능야호우대조조.량조재2년적수방기간균미출현엄중적불량반응.결론 장기소제량알전동연합미탁락이화배타보리비단용미탁락이화배타보리능경호지방치관심병성실성심률실상,병유조우심쇠적개선,가능환능감소재주원솔화졸사솔,료효명현우우단용배타보리화미탁락이,차무엄중불량반응발생.
Objective To observe the curative effect and seurity for ventficular arrhythmias induced by coronary artery disease by the combination of amiodarone,metoprolol and perindopril.Methods Sixty-three patients with ventricular arrhythmias induced by coronary artery disease with or not with heart failure were recruited consecutively from March 2003 to May 2007 who accepted treatmentes in our hospital.They were divided randomly into test group(33 cases)and control group(30 cases).On the routine treatment,the test group accepted amiodarone,metoprolol and pefindopril by PO,and the control group only metoprolol and perindopril.Results At the first and second year follow-up,the test group was better than the control group in curing ventricular arrhythmias and improving LVEF(P＞0.05),and might also be better in re-hospitalization rate and sudden death.Severe dys-reaction didn't be found in two groups.Conclusions The long-term and small-dosage combination of amiodarone,metoprolol and perindopril to treat ventricular arrhythmias induced by coronary artery disease with or without heart failure not only is better than only metoprolol and perindopril,but also is safe.
