国际中医中药杂志
國際中醫中藥雜誌
국제중의중약잡지
INTERNATIONAL JOURNAL OF TRIDITIONAL CHINESE MEDICINE
2012年
10期
893-895
,共3页
深部白色念珠菌感染%氟康唑%玉屏风散
深部白色唸珠菌感染%氟康唑%玉屏風散
심부백색념주균감염%불강서%옥병풍산
Deep candidiasis infection%Fluconazole%Yupingfeng dection
目的 探讨氟康唑与玉屏风散对深部白色念珠菌感染的疗效.方法 建立小鼠深部白色念珠菌病模型,观察氟康唑与玉屏风散对小鼠生存时间、小鼠腹腔巨噬细胞吞噬白色念珠菌的吞噬率(pp)及血清内一氧化氮(NO)、肿瘤坏死因子(TNF-α)含量的变化.结果 在非免疫抑制状态下,氟康唑组联合治疗组小鼠生存时间分别为(9.10±1.43)d、(9.20±1.62)d,与模型组[(8.00±1.63)d]比较,差异均有统计学意义(P均＜0.05).玉屏风散组血清中NO、TNF-α、pp含量分别为(90.00±4.50) μmol/L(0.52±0.05) nmol/L、(40.20±2.60)％,联合治疗组分别为(89.90±4.20) μmol/L、(0.45±0.05)nmo1/L、(40.50±2.50)％,与模型组[分别为(93.10±3.50) μmol/L、(3.98±0.31) nmol/L、(38.50±2.30)％]比较差异均有统计学意义(P均＜0.05).在免疫抑制状态下,玉屏风散组小鼠生存时间以及血清中NO、TNF-α pp含量分别为(7.90±1.86)d、(83.90±4.10) μmol/L、(0.72±0.05) nmol/L、(39.90±2.80)％,联合治疗组分别为(8.4±1.91)d、(83.50±4.20)μmol/L、(0.52±0.04) nmol/L、(39.20±1.90)％,与模型组(分别为(6.40±1.90)d、(86.60±3.80) μmol/L、(4.22±0.23) nmol/L、(25.30±2.30)％)比较,差异均有统计学意义(P均＜0.05).结论 玉屏风散与氟康唑合用对深部白色念珠菌感染的治疗有协同作用,可能与玉屏风散调节机体免疫、平衡体内炎症介质有关.
目的 探討氟康唑與玉屏風散對深部白色唸珠菌感染的療效.方法 建立小鼠深部白色唸珠菌病模型,觀察氟康唑與玉屏風散對小鼠生存時間、小鼠腹腔巨噬細胞吞噬白色唸珠菌的吞噬率(pp)及血清內一氧化氮(NO)、腫瘤壞死因子(TNF-α)含量的變化.結果 在非免疫抑製狀態下,氟康唑組聯閤治療組小鼠生存時間分彆為(9.10±1.43)d、(9.20±1.62)d,與模型組[(8.00±1.63)d]比較,差異均有統計學意義(P均＜0.05).玉屏風散組血清中NO、TNF-α、pp含量分彆為(90.00±4.50) μmol/L(0.52±0.05) nmol/L、(40.20±2.60)％,聯閤治療組分彆為(89.90±4.20) μmol/L、(0.45±0.05)nmo1/L、(40.50±2.50)％,與模型組[分彆為(93.10±3.50) μmol/L、(3.98±0.31) nmol/L、(38.50±2.30)％]比較差異均有統計學意義(P均＜0.05).在免疫抑製狀態下,玉屏風散組小鼠生存時間以及血清中NO、TNF-α pp含量分彆為(7.90±1.86)d、(83.90±4.10) μmol/L、(0.72±0.05) nmol/L、(39.90±2.80)％,聯閤治療組分彆為(8.4±1.91)d、(83.50±4.20)μmol/L、(0.52±0.04) nmol/L、(39.20±1.90)％,與模型組(分彆為(6.40±1.90)d、(86.60±3.80) μmol/L、(4.22±0.23) nmol/L、(25.30±2.30)％)比較,差異均有統計學意義(P均＜0.05).結論 玉屏風散與氟康唑閤用對深部白色唸珠菌感染的治療有協同作用,可能與玉屏風散調節機體免疫、平衡體內炎癥介質有關.
목적 탐토불강서여옥병풍산대심부백색념주균감염적료효.방법 건립소서심부백색념주균병모형,관찰불강서여옥병풍산대소서생존시간、소서복강거서세포탄서백색념주균적탄서솔(pp)급혈청내일양화담(NO)、종류배사인자(TNF-α)함량적변화.결과 재비면역억제상태하,불강서조연합치료조소서생존시간분별위(9.10±1.43)d、(9.20±1.62)d,여모형조[(8.00±1.63)d]비교,차이균유통계학의의(P균＜0.05).옥병풍산조혈청중NO、TNF-α、pp함량분별위(90.00±4.50) μmol/L(0.52±0.05) nmol/L、(40.20±2.60)％,연합치료조분별위(89.90±4.20) μmol/L、(0.45±0.05)nmo1/L、(40.50±2.50)％,여모형조[분별위(93.10±3.50) μmol/L、(3.98±0.31) nmol/L、(38.50±2.30)％]비교차이균유통계학의의(P균＜0.05).재면역억제상태하,옥병풍산조소서생존시간이급혈청중NO、TNF-α pp함량분별위(7.90±1.86)d、(83.90±4.10) μmol/L、(0.72±0.05) nmol/L、(39.90±2.80)％,연합치료조분별위(8.4±1.91)d、(83.50±4.20)μmol/L、(0.52±0.04) nmol/L、(39.20±1.90)％,여모형조(분별위(6.40±1.90)d、(86.60±3.80) μmol/L、(4.22±0.23) nmol/L、(25.30±2.30)％)비교,차이균유통계학의의(P균＜0.05).결론 옥병풍산여불강서합용대심부백색념주균감염적치료유협동작용,가능여옥병풍산조절궤체면역、평형체내염증개질유관.
Objective To observe the therapeutic effect offluconazole and Yupingfeng dection for the treatment of deep candidiasis in mice.Methods Set up the model of deep candidiasis in mice.Survival time,devour rate and content of NO,TNF-α are observed.Results In non-immunosuppressive condition,the survival time of Fluconazole and unit group was separately (9.10± 1.43) day and (9.20± 1.62)day.They had significant difference comparing with model group(8.00± 1.63)d.The content of NO,TNF and pp of Yupingfeng dection and unit group were (90.00±4.50)μmol/L,(0.52±0.05)nmol/L,(40.20±2.60)％ and (89.90±4.20) μmol/L,(0.45 ±0.05) nmol/L,(40.50±2.50) ％ separately.In immunosuppressive condition the survival time and content of NO TNF,pp of Yupingfeng dection and unit group had significance difference comparing with model group,which were (7.90 ± 1.86) day,(83.90± 4.10) μmol/L,(0.72 ± 0.05) nmol/L,(39.90±2.80) and (8.4± 1.91) day,(83.50 ±4.20) μmol/L,(0.52 ±0.04)nmol/L,(39.20± 1.90)％ separately,they had significant difference comparing with model group(6.40± 1.90)d,(86.60±3.80)μmol/L,(4.22±0.23)nmol/L,(25.30±2.30)％.Conclusion Yupingfeng dection had an effect for the treatment of deep candidiasis in mice particularly for the immunosuppressive mice.The combination of Yupingfeng dection and fluconazole can boost the therapeutic effect and its mechanism may be related to the immunoregulation.
