中华口腔医学杂志
中華口腔醫學雜誌
중화구강의학잡지
Chinese Journal of Stomatology
2012年
4期
208-213
,共6页
卢松鹤%闫志敏%魏明洁%高岩%华红
盧鬆鶴%閆誌敏%魏明潔%高巖%華紅
로송학%염지민%위명길%고암%화홍
干燥综合征%淋巴瘤%结节型舍格伦综合征
榦燥綜閤徵%淋巴瘤%結節型捨格倫綜閤徵
간조종합정%림파류%결절형사격륜종합정
Sj(o)gren's syndrome%Lymphoma%Tumor like Sj(o)gren's syndrome
目的 探讨结节型舍格伦综合征(tumor like Sj(o)gren’s syndrome,TLSS)与非TLSS( non-TLSS,NTLSS)患者临床、实验室特征及淋巴瘤的发生情况,以期为临床预测舍格伦综合征尤其是TLSS患者发生恶性淋巴瘤转化提供依据.方法 收集1998年1月至2010年1月就诊于北京大学口腔医学院·口腔医院并诊断为原发性舍格伦综合征或TLSS的患者199例,回顾性研究199例患者临床及实验室资料,根据有无腺体肿块将患者分为TLSS组(25例)及NTLSS组(174例),分析临床及实验室指标的差异并行统计学分析.结果 25例TLSS患者中23例为腮腺肿块,2例为颌下腺肿块；TLSS患者在腮腺造影阳性率(P =0.018)、γ球蛋白异常水平(P =0.014)、类风湿因子异常水平(P=0.001)、唇腺生发中心样结构形成(P=O.O14)、抗SSA抗体及抗SSB抗体双阳性率(P ＜0.001)方面与NTLSS患者差异均有统计学意义；25例TLSS患者中3例发生淋巴瘤,占入选病例总数的1.5％(3/199),占TLSS患者的12％ (3/25),3例淋巴瘤包括腹股沟区弥漫性大B细胞淋巴瘤1例及黏膜相关淋巴组织淋巴瘤2例；NTLSS患者无淋巴瘤发生.结论 TLSS与NTLSS患者在临床及实验室特征方面存在差异,TLSS患者更易出现淋巴瘤.
目的 探討結節型捨格倫綜閤徵(tumor like Sj(o)gren’s syndrome,TLSS)與非TLSS( non-TLSS,NTLSS)患者臨床、實驗室特徵及淋巴瘤的髮生情況,以期為臨床預測捨格倫綜閤徵尤其是TLSS患者髮生噁性淋巴瘤轉化提供依據.方法 收集1998年1月至2010年1月就診于北京大學口腔醫學院·口腔醫院併診斷為原髮性捨格倫綜閤徵或TLSS的患者199例,迴顧性研究199例患者臨床及實驗室資料,根據有無腺體腫塊將患者分為TLSS組(25例)及NTLSS組(174例),分析臨床及實驗室指標的差異併行統計學分析.結果 25例TLSS患者中23例為腮腺腫塊,2例為頜下腺腫塊；TLSS患者在腮腺造影暘性率(P =0.018)、γ毬蛋白異常水平(P =0.014)、類風濕因子異常水平(P=0.001)、脣腺生髮中心樣結構形成(P=O.O14)、抗SSA抗體及抗SSB抗體雙暘性率(P ＜0.001)方麵與NTLSS患者差異均有統計學意義；25例TLSS患者中3例髮生淋巴瘤,佔入選病例總數的1.5％(3/199),佔TLSS患者的12％ (3/25),3例淋巴瘤包括腹股溝區瀰漫性大B細胞淋巴瘤1例及黏膜相關淋巴組織淋巴瘤2例；NTLSS患者無淋巴瘤髮生.結論 TLSS與NTLSS患者在臨床及實驗室特徵方麵存在差異,TLSS患者更易齣現淋巴瘤.
목적 탐토결절형사격륜종합정(tumor like Sj(o)gren’s syndrome,TLSS)여비TLSS( non-TLSS,NTLSS)환자림상、실험실특정급림파류적발생정황,이기위림상예측사격륜종합정우기시TLSS환자발생악성림파류전화제공의거.방법 수집1998년1월지2010년1월취진우북경대학구강의학원·구강의원병진단위원발성사격륜종합정혹TLSS적환자199례,회고성연구199례환자림상급실험실자료,근거유무선체종괴장환자분위TLSS조(25례)급NTLSS조(174례),분석림상급실험실지표적차이병행통계학분석.결과 25례TLSS환자중23례위시선종괴,2례위합하선종괴；TLSS환자재시선조영양성솔(P =0.018)、γ구단백이상수평(P =0.014)、류풍습인자이상수평(P=0.001)、진선생발중심양결구형성(P=O.O14)、항SSA항체급항SSB항체쌍양성솔(P ＜0.001)방면여NTLSS환자차이균유통계학의의；25례TLSS환자중3례발생림파류,점입선병례총수적1.5％(3/199),점TLSS환자적12％ (3/25),3례림파류포괄복고구구미만성대B세포림파류1례급점막상관림파조직림파류2례；NTLSS환자무림파류발생.결론 TLSS여NTLSS환자재림상급실험실특정방면존재차이,TLSS환자경역출현림파류.
Objective To investigate the clinical and laboratory characteristics of tumor like Sj(o)gren's syndrome(TLSS) patients and non-tumor like Sj(o)gren's syndrome(NTLSS) and the incidence of lymphoma in patients of Sj(o)gren's syndrome(SS). Methods A retrospective analysis was carried out in 199 primary SS( including TLSS) patients who were recruited in Peking University School and Hospital of Stomatology from 1998 to 2010.Clinical and laboratory information were collected.The patients were divided into two groups:TLSS( n =25 ) and NTLSS (n =174 ).Clinical and laboratory characteristics wcrc comparcd between these two groups by a statistical analysis.Results Of the 25 TLSS patients,23 had enlargements of parotid glands and 2 had enlargements of submandibular glands. There were significant differences of salivary scintigraphy appearance ( P =0.018 ),hypergammaglobulinemia ( P =0.014 ),rheumatoid factor positive rate(P =0.001 ),formation of the ectopic germinal centers( P =0.014),double positive rate of anti-SSA antibody and anti-SSB antibody (P ＜ 0.001) between the TLSS and NTLSS patients.Among the 25 TLSS patients,3 developed lymphomas,accounting for 1.5％ (3/199) of the total 199 patients and 12％ (3/25) of the TLSS patients. Lymphoma subtypes included one diffused large B-cell lymphoma and two mucosa-associated lymphoid tissue lymphoma. There was no lymphoma detected in NTLSS patients.Conclusions There are clinical and laboratory differences between TLSS and NTLSS patients,with a more tendency to develop lymphomas in TLSS patients.
