CAJ | 학술논문

Hedgehog信号通路与哺乳动物的胚胎发育、组织发生以及肿瘤形成等有着密切的关系,在机体发育过程中调节细胞的增殖与分化.研究证实其在晚期前列腺癌中起着重要作用.在前列腺肿瘤异种移植动物模型中,将Hedgehog信号通路阻断后可以使瘤体变小.因此,靶向抑制Hedgehog信号通路可能对前列腺癌的治疗非常有效.
Hedgehog신호통로여포유동물적배태발육、조직발생이급종류형성등유착밀절적관계,재궤체발육과정중조절세포적증식여분화.연구증실기재만기전렬선암중기착중요작용.재전렬선종류이충이식동물모형중,장Hedgehog신호통로조단후가이사류체변소.인차,파향억제Hedgehog신호통로가능대전렬선암적치료비상유효.
Hedgehog signal pathway has close relationship with fetal development, histogenesis and carcinogenesis in mammalian. Recent studies have uncovered the role of Hedgehog signal pathway in advanced prostate cancer. Blockade of Hedgehog signal pathway leads to tumor shrinkage and remission in tumor xenograft models. Thus, targeted inhibition of Hedgehog signaling may have significant implications of prostate cancer therapeutics.