CAJ | 학술논문

目的研究α-氰基丙烯酸烷基酯类化学胶(化学胶)和纤维蛋白胶栓塞支气管的效果差异以及胰蛋白酶在其中的辅助作用.方法 30只新西兰兔完全随机分为化学胶组、纤维蛋白胶组、胰蛋白酶+化学胶组、胰蛋白酶+纤维蛋白胶组和单纯胰蛋白酶组.化学胶组、纤维蛋白胶组分别使用相应粘接剂栓塞兔肺支气管；胰蛋白酶+化学胶组、胰蛋白酶+纤维蛋白胶组先用猪胰蛋白酶预处理支气管,然后分别采用相应粘接剂栓塞兔肺支气管；单纯胰蛋白酶组只用猪胰蛋白酶处理支气管而不进行支气管栓塞.栓塞操作在X线透视下进行,通过CT扫描观察兔肺不张的发生发展.2周后处死动物,取出兔肺标本进行病理研究.结果化学胶组全部动物出现肺不张且持续到2周.纤维蛋白胶组栓塞后第2天4只动物出现短期的肺不张,10 d时已经全部复通.联合使用胰蛋白酶组肺组织病理有纤维组织增生.结论化学胶栓塞支气管效果优于纤维蛋白胶效果.栓塞前用胰蛋白酶预处理支气管能够使肺不张更加稳定,具有很好的协同作用.
목적 연구α-청기병희산완기지류화학효(화학효)화섬유단백효전새지기관적효과차이이급이단백매재기중적보조작용.방법 30지신서란토완전수궤분위화학효조、섬유단백효조、이단백매+화학효조、이단백매+섬유단백효조화단순이단백매조.화학효조、섬유단백효조분별사용상응점접제전새토폐지기관；이단백매+화학효조、이단백매+섬유단백효조선용저이단백매예처리지기관,연후분별채용상응점접제전새토폐지기관；단순이단백매조지용저이단백매처리지기관이불진행지기관전새.전새조작재X선투시하진행,통과CT소묘관찰토폐불장적발생발전.2주후처사동물,취출토폐표본진행병리연구.결과 화학효조전부동물출현폐불장차지속도2주.섬유단백효조전새후제2천4지동물출현단기적폐불장,10 d시이경전부복통.연합사용이단백매조폐조직병리유섬유조직증생.결론 화학효전새지기관효과우우섬유단백효효과.전새전용이단백매예처리지기관능구사폐불장경가은정,구유흔호적협동작용.
Objective To study the different effects of bronchial embolization between the fibrin glue and the chemical rubber and the additional role of the trypsin in bronchial embolization.Methods All 30 animals were randomly divided into five groups,including chemical rubber group,fibrin group,trypsin + chemical rubber group,trypsin + fibrin group and trypsin group (n =6 in each group).Embolizing bronchia with chemical rubber and fibrin glue was conducted respectively in chemical rubber group and fibrin group.Pretreating bronchiole with trypsin was done at first,and then the bronchiole was embolized in trypsin + chemical rubber group and trypsin + fibrin group.The embolism was done under the X-ray,then CT scan was used to detected the development of the pulmonary atelectasis.Two weeks after the embolism the animals were killed for lung pathology.Results All of the animals with the chemical rubber had the atelectasis.Only 4 cases of the animals with the fibrin glue appeared short-term atelectasis and all of them recovered in 10 days.The fibrous tissue proliferation could be seen in animals with the trypsin.Conclusions The effect of embolizing bronchia with the fibrin glue is not good enough.The chemical rubber of α- cyanoacrylate alkyl is more preferable.At same time pretreating bronchiole with tryPsin can enhance the embolism and get stable atelectasis.