CAJ | 학술논문

目的探讨慢性胃炎与胃癌组织中微血管密度、黏附分子的表达及对比意义.方法选取56例慢性浅表性胃炎患者(慢性浅表性胃炎组)、55例胃癌无淋巴结转移患者(胃癌无淋巴结转移组),57例胃癌有淋巴结转移患者(胃癌有淋巴结转移组)的病理组织蜡块,用免疫组织化学Envision法显示微血管密度CD34和细胞黏附分子Syndecan-1的表达情况,112例胃癌患者中高、中分化47例,低分化65例.结果 CD14表达以微血管密度计算:慢性浅表性胃炎组为(13 ± 10)个/高倍镜视野(HP),胃癌无淋巴结转移组为(27 ± 11)个/HP;胃癌有淋巴结转移组为(28 ±10)个/HP.慢性浅表性胃炎组与胃癌无淋巴结转移组及胃癌有淋巴结转移组比较差异有统计学意义(t=7.044、7.908,P＜0.05),胃癌无淋巴结转移组与胃癌有淋巴结转移组比较差异无统计学意义(t=0.506,P＞0.05.慢性浅表性胃炎组、胃癌无淋巴结转移组、胃癌有淋巴结转移组Syndecan-1阳性表达率分别为96.43%(54/56)、45.45%(25/55)、24.56%(14/57),慢性浅表性胃炎组与胃癌无淋巴结转移组及胃癌有淋巴结转移组比较差异有统计学意义(X2=163.560、17.197,P＜0.01).胃癌无淋巴结转移组与胃癌有淋巴结转移组比较差异有统计学意义(x2=5.340,P＜0.05).结论微血管密度增加与胃癌的发生有关;细胞黏附分子syndecan-1表达下调与胃癌的发生、发展有关,并可能进一步促进胃癌转移,检测微血管密度CD34及细胞黏附分子Syndecan-1的表达变化情况有助于胃癌的诊断及预后判断.
목적 탐토만성위염여위암조직중미혈관밀도、점부분자적표체급대비의의.방법 선취56례만성천표성위염환자(만성천표성위염조)、55례위암무림파결전이환자(위암무림파결전이조),57례위암유림파결전이환자(위암유림파결전이조)적병리조직사괴,용면역조직화학Envision법현시미혈관밀도CD34화세포점부분자Syndecan-1적표체정황,112례위암환자중고、중분화47례,저분화65례.결과 CD14표체이미혈관밀도계산:만성천표성위염조위(13 ± 10)개/고배경시야(HP),위암무림파결전이조위(27 ± 11)개/HP;위암유림파결전이조위(28 ±10)개/HP.만성천표성위염조여위암무림파결전이조급위암유림파결전이조비교차이유통계학의의(t=7.044、7.908,P＜0.05),위암무림파결전이조여위암유림파결전이조비교차이무통계학의의(t=0.506,P＞0.05.만성천표성위염조、위암무림파결전이조、위암유림파결전이조Syndecan-1양성표체솔분별위96.43%(54/56)、45.45%(25/55)、24.56%(14/57),만성천표성위염조여위암무림파결전이조급위암유림파결전이조비교차이유통계학의의(X2=163.560、17.197,P＜0.01).위암무림파결전이조여위암유림파결전이조비교차이유통계학의의(x2=5.340,P＜0.05).결론 미혈관밀도증가여위암적발생유관;세포점부분자syndecan-1표체하조여위암적발생、발전유관,병가능진일보촉진위암전이,검측미혈관밀도CD34급세포점부분자Syndecan-1적표체변화정황유조우위암적진단급예후판단.
Objective To investigate the clinical significance of the expression of microvessel density and adhesion molecules in the tissue of chronic gastritis and gastric cancer. Methods Fifty-six patients with chronic superficial gastritis (chronic superficial gastritis group), 55 cases of gastric cancer without lymph node metastasis (gastric cancer without lymph node metastasis group) and 57 patients with gastric cancer and lymph node metastasis (gastric cancer with lymph node metastasis group) were included in this study. Gastric pathology paraffin blocks was studied using immunohistochemical Envision method. Microvessel density CD34 and cell adhesion molecule Syndecan-1 expression was examined. In 112 gastric cancer patients, 47 patients were highly differentiated, and 65 patients were poorly differentiated. Results Microvessel density CD34 results:in chronic superficial gastritis group was (13 ± 10)/HP,in gastric cancer without lymph node metastasis group was (27 ± 11 VHP, in gastric cancer with lymph node metastasis group was (28 ± 10)/HP. There were significant differences between chronic superficial gastritis group and gastric cancer without lymph node metastasis group,and between chronic superficial gastritis group and gastric cancer with lymph node metastasis group (t = 7.044,7.908, P ＜0.05), but there was no significant difference between gastric cancer without lymph node metastasis group and gastric cancer with lymph node metastasis group (t = 0.506,P ＞ 0.05). In chronic superficial gastritis group, gastric cancer without lymph node metastasis group and gastric cancer with lymph node metastasis group, Syndecan-1 positive expression ratewas 96.43%(54/56),45.45%(25/55),24.56%(14/57),and there was significant difference between chronic superficial gastritis group and gastric cancer without lymph node metastasis group,and between chronic superficial gastritis group and gastric cancer with lymph node metastasis group (x2 = 163.560,17.197,P＜ 0.01). There was significant difference between gastric cancer without lymph node metastasis group and gastric cancer with lymph node metastasis group (x2 = 5.340, P ＜ 0.05). Conclusions Microvessel density is related with the occurrence of gastric cancer;adhesion molecule Syndecan-1 expression reduces the incidence of gastric cancer development, and might further promote the metastasis of gastric cancer. Detecting the expression changes of microvessel density CD34 and cell adhesion molecule Syndecan-1 facilitates the diagnosis and prognosis of gastric cancer.