中华普通外科杂志
中華普通外科雜誌
중화보통외과잡지
CHINESE JOURNAL OF GENERAL SURGERY
2010年
7期
562-565
,共4页
孙一来%赵渝%向志%邹中辉
孫一來%趙渝%嚮誌%鄒中輝
손일래%조투%향지%추중휘
疾病模型,动物%静脉血栓形成%血栓溶解疗法%抗凝药
疾病模型,動物%靜脈血栓形成%血栓溶解療法%抗凝藥
질병모형,동물%정맥혈전형성%혈전용해요법%항응약
Disease models,animal%Venous thrombosis%Thrombolytic therapy%Anticoagulants
目的 探讨蕲蛇酶联合肝素治疗兔急性下腔静脉血栓的有效性及安全性.方法 新西兰大白兔72只建立急性下腔静脉血栓模型后随机分为肝素组(A组)、尿激酶联合肝素组(B组)、蕲蛇酶联合肝素组(C组),每组24只.各组在血栓形成3 d后给药,分别在用药后的3、7、10 d检测各组凝血指标评估其安全性,通过静脉彩超评估其有效性.结果 C组的凝血酶原时间(prothrombin time,PT)延长时间较B组短(P<0.05),纤维蛋白原(fibrinogen,FBG)值较B组小(P<0.05),B组和C组PT延长时间较A组长(P<0.01),FBG值较A组大(P<0.01),B组和C组的D-二聚体值(D-dimer,D-D)均逐渐降至正常,差异无统计学意义(P>0.05).B组和C组的溶栓效果均较A组效果好,B组与A组差异有统计学意义(P<0.01),第10天时,C组与A组差异有统计学意义(P<0.01).B组和C组溶栓效果差异无统计学意义(P>0.05).结论 蕲蛇酶联合肝素治疗兔急性下腔静脉血栓是有效的,并且具有较高的安伞性.
目的 探討蘄蛇酶聯閤肝素治療兔急性下腔靜脈血栓的有效性及安全性.方法 新西蘭大白兔72隻建立急性下腔靜脈血栓模型後隨機分為肝素組(A組)、尿激酶聯閤肝素組(B組)、蘄蛇酶聯閤肝素組(C組),每組24隻.各組在血栓形成3 d後給藥,分彆在用藥後的3、7、10 d檢測各組凝血指標評估其安全性,通過靜脈綵超評估其有效性.結果 C組的凝血酶原時間(prothrombin time,PT)延長時間較B組短(P<0.05),纖維蛋白原(fibrinogen,FBG)值較B組小(P<0.05),B組和C組PT延長時間較A組長(P<0.01),FBG值較A組大(P<0.01),B組和C組的D-二聚體值(D-dimer,D-D)均逐漸降至正常,差異無統計學意義(P>0.05).B組和C組的溶栓效果均較A組效果好,B組與A組差異有統計學意義(P<0.01),第10天時,C組與A組差異有統計學意義(P<0.01).B組和C組溶栓效果差異無統計學意義(P>0.05).結論 蘄蛇酶聯閤肝素治療兔急性下腔靜脈血栓是有效的,併且具有較高的安傘性.
목적 탐토기사매연합간소치료토급성하강정맥혈전적유효성급안전성.방법 신서란대백토72지건립급성하강정맥혈전모형후수궤분위간소조(A조)、뇨격매연합간소조(B조)、기사매연합간소조(C조),매조24지.각조재혈전형성3 d후급약,분별재용약후적3、7、10 d검측각조응혈지표평고기안전성,통과정맥채초평고기유효성.결과 C조적응혈매원시간(prothrombin time,PT)연장시간교B조단(P<0.05),섬유단백원(fibrinogen,FBG)치교B조소(P<0.05),B조화C조PT연장시간교A조장(P<0.01),FBG치교A조대(P<0.01),B조화C조적D-이취체치(D-dimer,D-D)균축점강지정상,차이무통계학의의(P>0.05).B조화C조적용전효과균교A조효과호,B조여A조차이유통계학의의(P<0.01),제10천시,C조여A조차이유통계학의의(P<0.01).B조화C조용전효과차이무통계학의의(P>0.05).결론 기사매연합간소치료토급성하강정맥혈전시유효적,병차구유교고적안산성.
Objective To investigate the effectiveness and safety of combined heparin and acutobin in the treatment of acute inferior vena cava thrombus in rabbits. Methods The inferior vena cava thrombus model was established in 72 rabbits and they were randomly divided into three groups; heparin group(A) , group for combination of urokinase and heparin (B), group for combination of acutobin and heparin (C) ,each group including 24 rabbits. Drugs were administrated 3 days after thrombosis. Coagulation indexes were tested to assess their safety, and Doppler ultrasound was used to assess their effectiveness, on day 3, day 7, and day 10. Results The prolongation of prothrombin time ( PT) in group C was shorter than that in group B( P < 0. 05 ) , the fibrinogen ( FBG) value in group C was lower than that in group B (P < 0. 05 ) , the prolongation of PT in group B and group C was longer than that in group A (P < 0. 01), the FBG value of group B and C were higher than that in group A ( P < 0. 01 ), D-dimer ( D-D) value in group B and C gradually returned to normal range. There was no difference between the two groups (P > 0. 05). The thrombolytic effect in group B and C were better than that in group A, statistical difference was reached between groups B and A (P <0. 01), and the difference was statistically significant between groups C and A 10 days after administration (P < 0. 01). Thrombolytic effect was not different statistically between groups B and C (P > 0. 05). Conclusion Acutobin combined with heparin in the treatment of acute inferior vena cava thrombus in rabbits was effective and safe.
