中华流行病学杂志
中華流行病學雜誌
중화류행병학잡지
CHINESE JOURNAL OF EPIDEMIOLOGY
2011年
1期
60-67
,共8页
神经管畸形%基因多态性%5,10-亚甲基四氢叶酸还原酶%Meta分析
神經管畸形%基因多態性%5,10-亞甲基四氫葉痠還原酶%Meta分析
신경관기형%기인다태성%5,10-아갑기사경협산환원매%Meta분석
Neural tube defects%Genetic polymorphism%5,10-Methylenetrahydrofolate reeducates%Meta analysis
目的 定量评价双亲5,10-亚甲基四氢叶酸还原酶(MTHFR)基因C677T多态性与子代神经管畸形(NTDs)发生的关联性及关联强度,为利用双亲MTHFR 677位点基因型预测和评价子代NTDs的发病风险提供依据.方法 制定原始文献的纳入和排除标准及检索策略.检索中外数据库,收集有关亲代MTHFR基因C677T多态性与NTDs相关性的研究报告,按照MTHFR基因677位点基因型分类,分别整理子代患NTDs的双亲基因型频数数据,应用RevMan5.0软件对各文献进行异质性检验和Meta分析,得出合并后的OR值及其95%CI.结果 共33篇文献符合纳入标准.数据合并结果显示,母亲MTHFR基因677位点TT/CC、CT/CC基因型频率与子代NTDs易感性之间有统计学意义,OR值(95%CI)分别为1.68(1.32～2.14)、1.20(1.07～1.35);父亲MTHFR基因677位点TT/CC、CT/CC基因型频率与子代NTDs易感性有统计学意义,OR值(95%CI)分别为1.38(1.08～1.76)、1.32(1.13～1.55).结论 双亲MTHFR基因C677T多态性均是子代NTDs发病的重要危险因素.
目的 定量評價雙親5,10-亞甲基四氫葉痠還原酶(MTHFR)基因C677T多態性與子代神經管畸形(NTDs)髮生的關聯性及關聯彊度,為利用雙親MTHFR 677位點基因型預測和評價子代NTDs的髮病風險提供依據.方法 製定原始文獻的納入和排除標準及檢索策略.檢索中外數據庫,收集有關親代MTHFR基因C677T多態性與NTDs相關性的研究報告,按照MTHFR基因677位點基因型分類,分彆整理子代患NTDs的雙親基因型頻數數據,應用RevMan5.0軟件對各文獻進行異質性檢驗和Meta分析,得齣閤併後的OR值及其95%CI.結果 共33篇文獻符閤納入標準.數據閤併結果顯示,母親MTHFR基因677位點TT/CC、CT/CC基因型頻率與子代NTDs易感性之間有統計學意義,OR值(95%CI)分彆為1.68(1.32～2.14)、1.20(1.07～1.35);父親MTHFR基因677位點TT/CC、CT/CC基因型頻率與子代NTDs易感性有統計學意義,OR值(95%CI)分彆為1.38(1.08～1.76)、1.32(1.13～1.55).結論 雙親MTHFR基因C677T多態性均是子代NTDs髮病的重要危險因素.
목적 정량평개쌍친5,10-아갑기사경협산환원매(MTHFR)기인C677T다태성여자대신경관기형(NTDs)발생적관련성급관련강도,위이용쌍친MTHFR 677위점기인형예측화평개자대NTDs적발병풍험제공의거.방법 제정원시문헌적납입화배제표준급검색책략.검색중외수거고,수집유관친대MTHFR기인C677T다태성여NTDs상관성적연구보고,안조MTHFR기인677위점기인형분류,분별정리자대환NTDs적쌍친기인형빈수수거,응용RevMan5.0연건대각문헌진행이질성검험화Meta분석,득출합병후적OR치급기95%CI.결과 공33편문헌부합납입표준.수거합병결과현시,모친MTHFR기인677위점TT/CC、CT/CC기인형빈솔여자대NTDs역감성지간유통계학의의,OR치(95%CI)분별위1.68(1.32～2.14)、1.20(1.07～1.35);부친MTHFR기인677위점TT/CC、CT/CC기인형빈솔여자대NTDs역감성유통계학의의,OR치(95%CI)분별위1.38(1.08～1.76)、1.32(1.13～1.55).결론 쌍친MTHFR기인C677T다태성균시자대NTDs발병적중요위험인소.
Objective To explore the relationship between 5, 10-methylenetrahydrofolate reeducates gene polymorphism of the parents and the susceptibility to their offspring having neural tube defects. To forecast and evaluate the onset risk of neural tube defects (NTDs) on the basis of 5, 10-methylenetrahydrofolate reeducates (MTHFR) C677T polymorphism on parents of the patients.Methods Electronic search strategy was carried out among the five databases from home and abroad to collect qualified research papers, according to the inclusion and exclusion criteria. Case-control studies on association between MTHFR polymorphism and susceptibility to NTDs were collected and divided into two groups as mothers and fathers. The combined OR values and their 95% CI were calculated with Review Manager 5.0. Results 33 eligible studies were included. Statistics of the combined data showed a significant difference between the mothers with NTDs offspring carrying TT/CC, CT/CC of MTHFR gene C677T and controls. The pooled OR (95%CI) were 1.68 (1.32-2.14)and 1.20 (1.07-1.35) respectively. These was a significant difference between the fathers of the offspring with NTDs that carrying of TT/CC, CT/CC of MTHFR gene C677T and controls. The pooled ORs (95%CI) were 1.38 (1.08-1.76) and 1.32 (1.13-1.55) respectively. Conclusion The results suggested that the paternal and maternal MTHFR gene C677T polymorphism were risk factors to NTDs.
