CAJ | 학술논문

目的初步探讨玻璃体腔内注射Bevacizumab治疗视网膜新生血管性疾病术后早期眼压变化.方法对13例(18眼)视网膜新生血管性疾病,其中年龄相关性黄斑变性(10例,12眼)、糖尿病视网膜病变(3例,6眼),所有患者分别在第0周,6周,12周行玻璃体腔内注射Bevacizumab 1.25mg.在注射前后5min,30min,1h,2h进行眼压检查.结果以0周注射为例,5min,30min,1h,2h内眼压分别为(18.7±5.4)mmHg、(18.1±5.3)mmHg、(17.3±5.4)mmHg,与注射前平均眼压(14.6±4.1)mmHg相比差异有统计学意义(t值分别为2.81、3.45、2.63,P值均<0.05).而随访的2h平均眼压降为(15.6±5.8)mmHg,与注射前相比差异无统计学意义(t=0.15,P>0.5).在总共48次注射中,注射后眼压监测5min时IOP值高于正常眼压值(IOP>21mmHg)的百分率为41.7%,30min时高于正常眼压值的百分率为22.9%,而在1h内85.4%,2h内91.7%的眼压测量值恢复正常.结论玻璃体腔内注射Bevacizumab治疗视网膜新生血管性疾病早期眼压(5min)呈现短暂升高后下降,术后2h可作为门诊玻璃体腔内注射Bevacizumab早期眼压监测时间点.
목적 초보탐토파리체강내주사Bevacizumab치료시망막신생혈관성질병술후조기안압변화.방법 대13례(18안)시망막신생혈관성질병,기중년령상관성황반변성(10례,12안)、당뇨병시망막병변(3례,6안),소유환자분별재제0주,6주,12주행파리체강내주사Bevacizumab 1.25mg.재주사전후5min,30min,1h,2h진행안압검사.결과 이0주주사위례,5min,30min,1h,2h내안압분별위(18.7±5.4)mmHg、(18.1±5.3)mmHg、(17.3±5.4)mmHg,여주사전평균안압(14.6±4.1)mmHg상비차이유통계학의의(t치분별위2.81、3.45、2.63,P치균<0.05).이수방적2h평균안압강위(15.6±5.8)mmHg,여주사전상비차이무통계학의의(t=0.15,P>0.5).재총공48차주사중,주사후안압감측5min시IOP치고우정상안압치(IOP>21mmHg)적백분솔위41.7%,30min시고우정상안압치적백분솔위22.9%,이재1h내85.4%,2h내91.7%적안압측량치회복정상.결론 파리체강내주사Bevacizumab치료시망막신생혈관성질병조기안압(5min)정현단잠승고후하강,술후2h가작위문진파리체강내주사Bevacizumab조기안압감측시간점.
Objective To assess short-term trends and the need to monitor intraocular pressure (IOP) changes immediately after intraocular injection of bevacizumab for retinal neovasularization disease.Methods A total of 18 eyes of 13 consecutive patients including 10 cases of neovasular aged-related macular degeneration (12 eyes), 3 cases of diabetic retinopathy (6 eyes) diseases received a single bevacizumab intravitreal injection of 1.25mg at 0th week, 6th week and 12th week. Intraocular pressures were measured before injection, immediately after injection at the time of 5min, 30min, 1h and 2h.Results Take 0 week as an example, the mean intraocular pressure was increased remarkably at the follow-up time of 5 min, 30min, 1h, [(18.7±5.4) nan Hg, (18.1±5.3) mmHg, (17.3±5.4) mmHg] compared with those before injection [(14.6±4.1) mmHg, t values were 2.81, 3.45, 2.63 respectively, P<0.05].However, the mean intraocular pressure at 2h (15.6±5.8) mmHg shows no significant difference comparing with the value before injection (t=0.15, P>0.5).During a total of 48 injections, 41.7% IOP value at 5min is higher than the normal value (IOP>21mmHg), and the percentage decreased to 22.9% at 30min.Nevertheless, 85.4%, 91.7% of IOP value returns back to normal at lh, 2h respectively.Conclusions Elevations in IOP immediately (5min) after intravitreal injections are common, but are transient during the treatment of intravitreal injections of bevacizumab for retinal neovasularizafion disease which indicates that 2h could be taken as the monitoring short term IOP time point for the out-patients.