中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2012年
13期
1931-1932
,共2页
何建华%喻文才%曾钦文%张顺琼
何建華%喻文纔%曾欽文%張順瓊
하건화%유문재%증흠문%장순경
153钐-乙二胺四甲基膦酸%伊班膦酸钠%骨转移%肺肿瘤%放射性核素
153釤-乙二胺四甲基膦痠%伊班膦痠鈉%骨轉移%肺腫瘤%放射性覈素
153삼-을이알사갑기련산%이반련산납%골전이%폐종류%방사성핵소
153Sm-EDTMP%Ibandranate%Osseous metastasis%Lung neoplasms%Radionuclide
目的 探讨153钐-乙二胺四甲基膦酸(153 Sm-EDTMP)核素加伊班膦酸钠(艾本)治疗肺癌骨转移骨痛的疗效.方法 100例肺癌骨转移患者随机分为153Sm-EDTMP加伊班膦酸钠静脉滴注52例(治疗组)、单用153Sm-EDTMP核素治疗组48例(对照组),比较两组止痛效果、活动能力、生活质量改善、溶骨病灶的修复及毒副作用.结果 治疗组疼痛总缓解率为94.2％,明显高于对照组的64.5％(x2=4.78,P＜0.05)；治疗组活动能力改善状况的总有效率为82.6％,明显高于对照组的64.5％(x2=4.13,P＜0.05)；治疗组生活质量改善状况的总有效率为84.6％,明显高于对照的62.5％(x2 =4.58,P＜0.05)；两组毒副作用差异无统计学意义(x2=0.345,P＞0.05).结论 153Sm-EDTMP联合治疗肺癌骨转移,具有止痛、改善活动能力、提高生治质量的疗效.
目的 探討153釤-乙二胺四甲基膦痠(153 Sm-EDTMP)覈素加伊班膦痠鈉(艾本)治療肺癌骨轉移骨痛的療效.方法 100例肺癌骨轉移患者隨機分為153Sm-EDTMP加伊班膦痠鈉靜脈滴註52例(治療組)、單用153Sm-EDTMP覈素治療組48例(對照組),比較兩組止痛效果、活動能力、生活質量改善、溶骨病竈的脩複及毒副作用.結果 治療組疼痛總緩解率為94.2％,明顯高于對照組的64.5％(x2=4.78,P＜0.05)；治療組活動能力改善狀況的總有效率為82.6％,明顯高于對照組的64.5％(x2=4.13,P＜0.05)；治療組生活質量改善狀況的總有效率為84.6％,明顯高于對照的62.5％(x2 =4.58,P＜0.05)；兩組毒副作用差異無統計學意義(x2=0.345,P＞0.05).結論 153Sm-EDTMP聯閤治療肺癌骨轉移,具有止痛、改善活動能力、提高生治質量的療效.
목적 탐토153삼-을이알사갑기련산(153 Sm-EDTMP)핵소가이반련산납(애본)치료폐암골전이골통적료효.방법 100례폐암골전이환자수궤분위153Sm-EDTMP가이반련산납정맥적주52례(치료조)、단용153Sm-EDTMP핵소치료조48례(대조조),비교량조지통효과、활동능력、생활질량개선、용골병조적수복급독부작용.결과 치료조동통총완해솔위94.2％,명현고우대조조적64.5％(x2=4.78,P＜0.05)；치료조활동능력개선상황적총유효솔위82.6％,명현고우대조조적64.5％(x2=4.13,P＜0.05)；치료조생활질량개선상황적총유효솔위84.6％,명현고우대조적62.5％(x2 =4.58,P＜0.05)；량조독부작용차이무통계학의의(x2=0.345,P＞0.05).결론 153Sm-EDTMP연합치료폐암골전이,구유지통、개선활동능력、제고생치질량적료효.
Objective To explore the effect of 153Sm-EDTMP combined ibandranate in treatment of osseous metastasis of lung cancer.Methods 100 patients with osseous metastasis of lung cancer were randomly divided into two groups.The patients received intervenous drop infusion of 153Sm-EDTMP and ibandranate in treatment group( n =52).The patients received therapy with 153Sm-EDTMP in control group( n =48).The differentces of effect of odynolysis,locomotor activity,improvement of quality of life,recovery of osteolysis,toxical and adverse reaction between two groups were compared.Results The overall response rate 94.2％ in treatment group was significantly higher than that 64.5 ％ in control group( x2 =4.78,P ＜ 0.0.5 ) ;The activity to improve situation 82.6％ in treatment group was significantly higher than that 64.5％ in control group( x2 =4.13,P ＜ 0.05 ) ;The total effective rate of quality of life improve the situation 84.6％ in treatment group was significantly higher than that 62.5％ in control group( x2 =4.58,P ＜0.05 ) ;The side effects had no significant difference between two groups ( x2 =0.345,P ＞ 0.05).Conclusion The treatment of 153Sm-EDTMP combined with ibandranate in the treatment of osseous-metastasis of lung cancer was effective for relieving pain,improvement locomotor activity,improvement of quality of life,recovery of osteolysis.
