中国小儿急救医学
中國小兒急救醫學
중국소인급구의학
CHINESE PEDIATRIC EMERGENCY MEDICINE
2011年
5期
455-457
,共3页
肺炎支原体肺炎%发病机制%细胞因子%儿童
肺炎支原體肺炎%髮病機製%細胞因子%兒童
폐염지원체폐염%발병궤제%세포인자%인동
Mycoplasma pneumoniae pneumonia%Pathogenesis%Cytokines%Children
细胞因子及细胞免疫在肺炎支原体肺炎的发病机制中发挥重要的作用.研究显示肺炎支原体感染时,白介素-4(interleukin-4,IL-4)、干扰素-γ、IL-6、IL-13浓度增高,IL-10浓度降低.IL-2、IL-8、肿瘤坏死因子-α浓度变化各研究结果仍有分歧,仍需进一步深入探讨.通过临床监测多种细胞因子的浓度改变,能够为明确诊断肺炎支原体肺炎、判断感染轻重、预测预后提供依据,为今后肺炎支原体肺炎开展免疫治疗提供理论基础.
細胞因子及細胞免疫在肺炎支原體肺炎的髮病機製中髮揮重要的作用.研究顯示肺炎支原體感染時,白介素-4(interleukin-4,IL-4)、榦擾素-γ、IL-6、IL-13濃度增高,IL-10濃度降低.IL-2、IL-8、腫瘤壞死因子-α濃度變化各研究結果仍有分歧,仍需進一步深入探討.通過臨床鑑測多種細胞因子的濃度改變,能夠為明確診斷肺炎支原體肺炎、判斷感染輕重、預測預後提供依據,為今後肺炎支原體肺炎開展免疫治療提供理論基礎.
세포인자급세포면역재폐염지원체폐염적발병궤제중발휘중요적작용.연구현시폐염지원체감염시,백개소-4(interleukin-4,IL-4)、간우소-γ、IL-6、IL-13농도증고,IL-10농도강저.IL-2、IL-8、종류배사인자-α농도변화각연구결과잉유분기,잉수진일보심입탐토.통과림상감측다충세포인자적농도개변,능구위명학진단폐염지원체폐염、판단감염경중、예측예후제공의거,위금후폐염지원체폐염개전면역치료제공이론기출.
Cytokines and cellular immunity play a major role in the pathogenesis of mycoplasma pneumoniae pneumonia(MPP).Studies have shown that mycoplasma pneumoniae infection,the concentrations of interleukin(IL)-4,interferon-γ,IL-6 and IL-13 increased,but the concentration of IL-10 decreased.The concentrations of IL-2,IL-8 and tumor necrosis factor-α have various results which still need further discussion.Through clinical monitoring of a variety of cytokines by the changes of concentrations,it can confirm the diagnosis of MPP,determine the severity of infection,provide the basis for prognosis and provide the theoretical basis for immunotherapy of MPP.
