华中科技大学学报（医学版）
華中科技大學學報（醫學版）
화중과기대학학보（의학판）
ACTA UNIVERSITATIS MEDICINAE TONGJI
2010年
1期
133-135
,共3页
直肠癌%环周切缘癌浸润%免疫组化技术%病理大组织切片
直腸癌%環週切緣癌浸潤%免疫組化技術%病理大組織切片
직장암%배주절연암침윤%면역조화기술%병리대조직절편
rectal cancer%circumferential margin invasion%immunohistochemistry%pathological large slices
目的 苏木精-伊红染色病理大切片结合免疫组化指标CK20检测中、低位直肠癌系膜环周切缘癌浸润(CMI)的存在规律,为直肠癌的临床治疗提供病理学依据.方法 随机选取8个月期间中、低位直肠癌患者41例,手术标本制作成苏木精-伊红染色及免疫组化SP法染色的病理大切片进行检测.结果苏木精-伊红染色及免疫组化SP法染色病理大切片检测中、下段直肠癌系膜CMI阳性率分别为21.95%、29.27%.在肿瘤高、中分化组CMI阳性率低于低分化组(P＜0.05).肿瘤下缘距齿线距离＜5 cm组CMI阳性率高于≥5 cm组(P＜0.05).患者性别、年龄、肿瘤大体类型、浸润深度、淋巴结转移情况、手术方法 均与CMI阳性率无明显相关性(均P＞0.05).结论 肿瘤分化程度低、肿瘤位置低是CMI存在的高危因素.对于存在CMI者,术后应行规范的辅助治疗.
目的 囌木精-伊紅染色病理大切片結閤免疫組化指標CK20檢測中、低位直腸癌繫膜環週切緣癌浸潤(CMI)的存在規律,為直腸癌的臨床治療提供病理學依據.方法 隨機選取8箇月期間中、低位直腸癌患者41例,手術標本製作成囌木精-伊紅染色及免疫組化SP法染色的病理大切片進行檢測.結果囌木精-伊紅染色及免疫組化SP法染色病理大切片檢測中、下段直腸癌繫膜CMI暘性率分彆為21.95%、29.27%.在腫瘤高、中分化組CMI暘性率低于低分化組(P＜0.05).腫瘤下緣距齒線距離＜5 cm組CMI暘性率高于≥5 cm組(P＜0.05).患者性彆、年齡、腫瘤大體類型、浸潤深度、淋巴結轉移情況、手術方法 均與CMI暘性率無明顯相關性(均P＞0.05).結論 腫瘤分化程度低、腫瘤位置低是CMI存在的高危因素.對于存在CMI者,術後應行規範的輔助治療.
목적 소목정-이홍염색병리대절편결합면역조화지표CK20검측중、저위직장암계막배주절연암침윤(CMI)적존재규률,위직장암적림상치료제공병이학의거.방법 수궤선취8개월기간중、저위직장암환자41례,수술표본제작성소목정-이홍염색급면역조화SP법염색적병리대절편진행검측.결과소목정-이홍염색급면역조화SP법염색병리대절편검측중、하단직장암계막CMI양성솔분별위21.95%、29.27%.재종류고、중분화조CMI양성솔저우저분화조(P＜0.05).종류하연거치선거리＜5 cm조CMI양성솔고우≥5 cm조(P＜0.05).환자성별、년령、종류대체류형、침윤심도、림파결전이정황、수술방법 균여CMI양성솔무명현상관성(균P＞0.05).결론 종류분화정도저、종류위치저시CMI존재적고위인소.대우존재CMI자,술후응행규범적보조치료.
Objective To study the rules of circumferential margin invasion(CMI)in middle and(or)lower rectal cancers by pathological large slices stained with HE and labeled with CK20,and provide a pathological basis for clinical therapy of rectal cancer.Methods Forty-one patients with middle or low rectal cancer were randomly selected in 8 months.The surgically resected specimens were detected after they were made into the pathological large slices stained with HE and labeled with CK20.Results The mesentery CMI positive rate in the pathological slices with HE staining and CK20 labeling was 21.95%,and 29.27% respectively.The mesentery CMI positive rate in moderately-and well-differentiated group was lower than in poorly-differentiated group(P＜0.05).Moreover,the mesentery CMI rate was higher in the specimens with lower edge less than 5 cm away from the dentate line than that in those with lower edge more than 5 cm away from the dentate line(P＜0.05).There was no significant correlation between CMI with the factors such as gender,age,pathological general types,tumor infiltration depth,lymph node metastasis,and surgical procedures(all P＞0.05).Conclusion There were risk factors for the CMI such as low location,poor differentiation and so on.The CMI patients should be treated with standardized adjunctive therapy after operation.
