CAJ | 학술논문

Rap 1是Ras超家族中一种微小G蛋白.在不同的组织细胞中,Rap1在调节细胞增殖、分化以及黏附方面都发挥着十分重要的作用.在调控细胞增殖和分化的过程中,Rap 1可能通过调控细胞内促丝裂原活化蛋白激酶(MAPK)以及细胞外信号激酶(ERK)通路来发挥作用.Rap1对特定种类细胞的ERK信号途径是增强还是减弱,取决于该种细胞是否具有Raf 1或B-Raf.Rap1调控的活性通路独立于Ras通路,但两者之间又相互作用.而Ras基因的致癌突变发生在超过30%的人类恶性肿瘤中.本综述对Rap1在造血细胞发育中的调控功能,以及它在恶性血液病中的改变和作用作一简明扼要的介绍.
Rap 1시Ras초가족중일충미소G단백.재불동적조직세포중,Rap1재조절세포증식、분화이급점부방면도발휘착십분중요적작용.재조공세포증식화분화적과정중,Rap 1가능통과조공세포내촉사렬원활화단백격매(MAPK)이급세포외신호격매(ERK)통로래발휘작용.Rap1대특정충류세포적ERK신호도경시증강환시감약,취결우해충세포시부구유Raf 1혹B-Raf.Rap1조공적활성통로독립우Ras통로,단량자지간우상호작용.이Ras기인적치암돌변발생재초과30%적인류악성종류중.본종술대Rap1재조혈세포발육중적조공공능,이급타재악성혈액병중적개변화작용작일간명액요적개소.
Rapl is a small G protein belonging to the RAS superfamily. Rapl signalling has effects on cell growth, cell proliferation and involves in regulation of the mitogen activated protein (MAP) kinase or ERK (extracellular sig-nal regulated kinase) cascade. Rapl will directly activate ERK through B-Raf. B-Raf is a member of Raf family, and presents in neuronal and hematopoietic cells. Oncogenie mutations of gene RAS are most frequent and detected in 20%-30% of human leukemias and 10%-15% of MDS eases. The review summarizes the regulatory function of Rapl in development of hematopoietie cells and effect of Rapl in hematologic malignancies.