CAJ | 학술논문

目的评价原发性血小板减少性紫癜(idiopathic thrombocytopenic purpura,ITP)几种检测指标的诊断价值.方法对ITP组、健康对照组、非ITP组采用流式细胞仪检测网织血小板(reticulated platele,RP),ELISA方法检测血小板相关抗体(platelet-associated immunoglobulins,PAIgG、促血小板生成素(thrombopoietin,TPO);血细胞分析仪检测血小板相关参数:血小板平均体积(mean platelet volume,MPV、血小板的分布宽度(platelet distribution width,PDW).大血小板比率(platelet-large cell ratio,P-LCR),对所得数据应用receiver operating characteristic(ROC)曲线、LSD-t检验、多元回归分析、相关性分析等多种统计学方法进行分析.结果 ITP组RP、MPV、PDW、P-LCR、PAIgG高于健康对照组和非ITP组(P<0.05),非ITP组TPO水平明显高于健康对照组和ITP组(P<0.05).RP和PAIgG对于ITP诊断的灵敏度高,有一定的诊断价值,且RP与ITP诊断相关(P=0.006),几种检测指标与血小板数均无相关性,检测指标间PAIgG与RP有相关性(P=0.013).结论血小板相关抗体、网织血小板、血小板参数、促血小板生成素等检测方法简便,各指标单独应用对ITP的诊断效能不够,多指标联合使用可以提高ITP的诊断价值.
목적 평개원발성혈소판감소성자전(idiopathic thrombocytopenic purpura,ITP)궤충검측지표적진단개치.방법 대ITP조、건강대조조、비ITP조채용류식세포의검측망직혈소판(reticulated platele,RP),ELISA방법검측혈소판상관항체(platelet-associated immunoglobulins,PAIgG、촉혈소판생성소(thrombopoietin,TPO);혈세포분석의검측혈소판상관삼수:혈소판평균체적(mean platelet volume,MPV、혈소판적분포관도(platelet distribution width,PDW).대혈소판비솔(platelet-large cell ratio,P-LCR),대소득수거응용receiver operating characteristic(ROC)곡선、LSD-t검험、다원회귀분석、상관성분석등다충통계학방법진행분석.결과 ITP조RP、MPV、PDW、P-LCR、PAIgG고우건강대조조화비ITP조(P<0.05),비ITP조TPO수평명현고우건강대조조화ITP조(P<0.05).RP화PAIgG대우ITP진단적령민도고,유일정적진단개치,차RP여ITP진단상관(P=0.006),궤충검측지표여혈소판수균무상관성,검측지표간PAIgG여RP유상관성(P=0.013).결론 혈소판상관항체、망직혈소판、혈소판삼수、촉혈소판생성소등검측방법간편,각지표단독응용대ITP적진단효능불구,다지표연합사용가이제고ITP적진단개치.