国际眼科杂志
國際眼科雜誌
국제안과잡지
INTERNATIONAL JOURNAL OF OPHTHALMOLOGY
2007年
5期
1197-1201
,共5页
彭洁%邹艳红%江伟%张奕华%计晓斌%沈子龙%彭司勋%邱春亿
彭潔%鄒豔紅%江偉%張奕華%計曉斌%瀋子龍%彭司勛%邱春億
팽길%추염홍%강위%장혁화%계효빈%침자룡%팽사훈%구춘억
ZX-5%(R,R)-ZX-5%(S,S)-ZX-5%脉络膜%视网膜
ZX-5%(R,R)-ZX-5%(S,S)-ZX-5%脈絡膜%視網膜
ZX-5%(R,R)-ZX-5%(S,S)-ZX-5%맥락막%시망막
ZX-5%(R,R)-ZX-5%(S,S)-ZX-5%choroid%retina
目的:研究ZX-5对缺血后视网膜功能的恢复作用,并比较其光学异构体(R,R)-ZX-5和(S,S)-ZX-5对脉络膜血流及缺血后视网膜功能恢复的影响.方法:用彩色微球技术研究兔高眼压下(40 mmHg)脉络膜血流的变化.用视网膜电生理仪测量b波,评价大鼠缺血后视网膜功能的恢复情况.结果:10g/L (R,R)-ZX-5滴眼液50μL能在不同时间点提高脉络膜血流(P＜0.05),而(S,S)-ZX-5在相同条件下对提高脉络膜血流没有影响.ZX-5和(R, R)-ZX-5在不同时间点对视网膜缺血后功能恢复作用明显(P＜0.05),(R, R)-ZX-5的作用优于ZX-5;而(S,S)-ZX-5对缺血后视网膜功能的恢复作用不明显.结论:ZX-5和(R, R)-ZX-5对增加脉络膜血流量和促进视网膜功能的恢复有显著功效,(R, R)-ZX-5恢复视网膜功能的作用更强,有可能进一步开发成有效防治眼血流障碍相关性眼病的药物.
目的:研究ZX-5對缺血後視網膜功能的恢複作用,併比較其光學異構體(R,R)-ZX-5和(S,S)-ZX-5對脈絡膜血流及缺血後視網膜功能恢複的影響.方法:用綵色微毬技術研究兔高眼壓下(40 mmHg)脈絡膜血流的變化.用視網膜電生理儀測量b波,評價大鼠缺血後視網膜功能的恢複情況.結果:10g/L (R,R)-ZX-5滴眼液50μL能在不同時間點提高脈絡膜血流(P＜0.05),而(S,S)-ZX-5在相同條件下對提高脈絡膜血流沒有影響.ZX-5和(R, R)-ZX-5在不同時間點對視網膜缺血後功能恢複作用明顯(P＜0.05),(R, R)-ZX-5的作用優于ZX-5;而(S,S)-ZX-5對缺血後視網膜功能的恢複作用不明顯.結論:ZX-5和(R, R)-ZX-5對增加脈絡膜血流量和促進視網膜功能的恢複有顯著功效,(R, R)-ZX-5恢複視網膜功能的作用更彊,有可能進一步開髮成有效防治眼血流障礙相關性眼病的藥物.
목적:연구ZX-5대결혈후시망막공능적회복작용,병비교기광학이구체(R,R)-ZX-5화(S,S)-ZX-5대맥락막혈류급결혈후시망막공능회복적영향.방법:용채색미구기술연구토고안압하(40 mmHg)맥락막혈류적변화.용시망막전생리의측량b파,평개대서결혈후시망막공능적회복정황.결과:10g/L (R,R)-ZX-5적안액50μL능재불동시간점제고맥락막혈류(P＜0.05),이(S,S)-ZX-5재상동조건하대제고맥락막혈류몰유영향.ZX-5화(R, R)-ZX-5재불동시간점대시망막결혈후공능회복작용명현(P＜0.05),(R, R)-ZX-5적작용우우ZX-5;이(S,S)-ZX-5대결혈후시망막공능적회복작용불명현.결론:ZX-5화(R, R)-ZX-5대증가맥락막혈류량화촉진시망막공능적회복유현저공효,(R, R)-ZX-5회복시망막공능적작용경강,유가능진일보개발성유효방치안혈류장애상관성안병적약물.
AIM: The effects of ZX-5, as nitric oxide (NO) donor, on ocular blood flow has been investigated using colored microsphere technique in previous study. The relationship between the production of NO by ZX-5 and ocular blood flow has been evaluated. ZX-5 has been shown to have strong positive effect on increasing choroidal blood flow. However,the effect of ZX-5 on retinal function recovery, the effects of its optical isomers, (R, R)-ZX-5 and (S, S)-ZX-5, on choroidal blood flow and retinal function recovery have not been studied and merit investigation.METHODS: Colored microsphere technique was used for in vivo experiments to determine choroidal blood flow of ocular hypertension (40mmHg) in rabbit eyes. Electroretinography was used to measure the b-wave recovery as an indication of retinal function recovery.RESULTS: (R, R)-ZX-5 increased choroidal blood flow at 10g/L, 50μL instillation into eyes at all time points (P＜0.05).(S, S)-ZX-5 was not effective in increasing choroidal blood flow. ZX-5 and (R, R)-ZX-5 showed significant effects in retinal function recovery after ischemia of the retina at all time points (P＜0.05); whereas (S, S)-ZX-5 did not show significant effect on recovery of b-wave after ischemia at most time points except at 120 and 240 minutes.CONCLUSION: ZX-5 and (R, R)-ZX-5 have high potency in increasing the choroidal blood flow and improving the retinal function recovery. It is hoped that they could be used for the prevention/treatment of ocular blood flow related eye diseases.
