CAJ | 학술논문

　　目的：对阿霉素脂质体冻干工艺进行考察。方法：以外观、再分散性、粒径为指标，对冻干工艺中参数进行优化。结果：优化的冻干工艺为-75℃预冻24h，升温至-25℃保持16h，再升温至20℃持续8h，选择10%海藻糖作为阿霉素脂质体的冻干保护剂。结论：通过优化冻干工艺参数，所得的阿霉素脂质体冻干制品外观平整、质地疏松，加水后能迅速分散均匀。
　　목적：대아매소지질체동간공예진행고찰。방법：이외관、재분산성、립경위지표，대동간공예중삼수진행우화。결과：우화적동간공예위-75℃예동24h，승온지-25℃보지16h，재승온지20℃지속8h，선택10%해조당작위아매소지질체적동간보호제。결론：통과우화동간공예삼수，소득적아매소지질체동간제품외관평정、질지소송，가수후능신속분산균균。
Objietive:To optimize the preparation and formulation of the freez-drying Liposomes. Methods: The physicochemical properties of liposome before and after freez-drying were studied,such as particle shape,appearance and particle diameter. Results:Processing factors were optimized base on the optimized preparation and formulation:frozen time 24h,heating-up to-25℃16h,then heating-up to 20℃ 8h. Trehalose was ensure to protect liposome as cryoprotectant. Conclusions: The optimized preparation and formulation can be used to prepare docetaxel liposome successfully.