CAJ | 학술논문

目的探索母牛分支杆菌疫苗在治疗癌性胸液中的作用。方法肺癌并癌性胸液40例，配对随机分组，治疗组胸腔内灌注母牛分支杆菌疫苗 1000μg 2～3次，对照组胸腔内灌注顺铂40～60mg 2～3次，两组均同时给以全身化疗。结果治疗组完全有效率60%(12/20)明显高于对照组20%(4/20)，治疗组的有效率90%(18/20)亦高于对照组的55%(11/20)，P＜0.05。结论母牛分支杆菌疫苗可用于癌性胸液的局部治疗。
목적탐색모우분지간균역묘재치료암성흉액중적작용。방법폐암병암성흉액40례，배대수궤분조，치료조흉강내관주모우분지간균역묘 1000μg 2～3차，대조조흉강내관주순박40～60mg 2～3차，량조균동시급이전신화료。결과치료조완전유효솔60%(12/20)명현고우대조조20%(4/20)，치료조적유효솔90%(18/20)역고우대조조적55%(11/20)，P＜0.05。결론모우분지간균역묘가용우암성흉액적국부치료。
Objective　To determine the effects of intrapleural injection of Mycobacterium vaccae vaccine for patients with lung cancer and pleural effusion. Methods　40 patients with lung cancer and malignant pleural effusion were divided into study group and control group at random pair.Mycobacterium vaccae vaccine 1000μg were injected into the pleural cavity once weekly for 2～3 weeks for the control group. Results　90%(18/20) of the study group achieved partial relief and 60%(12/20) had complete relief. Both of which were significant higher than those of the control group(P＜0.05),while 55%(11/20) of the control group achieved partial relief and 20%(4/20) had complete relief,after 1yr follow-up,the relapse rat of pleural effusion of the study group was 5%(1/18),and the control group was 46%(5/11),P＜0.05. Conclusion　As adjunct to chemotherapy,Mycobacterium vaccae vaccine is helpful for patients with lung cancer and malignant pleural effusion.