CAJ | 학술논문

对含吲哚美辛的固定式铜宫内节育器(FICu-IUD)进行了动物毒理学实验.结果显示:尾静脉注射吲哚美辛硅橡胶浸提液对小鼠无全身急性毒性.FICu-IUD对家兔子宫局部刺激和损伤较FCu-IUD明显减轻.长期毒性试验,吲哚美辛对大鼠的体重增长、血液学及血液生化指标无明显影响;脏器系数和病理组织学检查,除子宫外,无明显异常.经口给予吲哚美辛硅橡胶浸提液,对大鼠无明显致畸敏感期生殖毒性.提示:FICu-IUD毒性小,用于临床安全.
대함신타미신적고정식동궁내절육기(FICu-IUD)진행료동물독이학실험.결과현시:미정맥주사신타미신규상효침제액대소서무전신급성독성.FICu-IUD대가토자궁국부자격화손상교FCu-IUD명현감경.장기독성시험,신타미신대대서적체중증장、혈액학급혈액생화지표무명현영향;장기계수화병리조직학검사,제자궁외,무명현이상.경구급여신타미신규상효침제액,대대서무명현치기민감기생식독성.제시:FICu-IUD독성소,용우림상안전.
The toxicological experiment was performed on fix-indomethacin-releasing copper intrauterine device (FICu-IUD). The results showed that no systematic acute toxicity occurred in mouse after injection of indomethacin and medicinal silico gel via tail vein. The local stimulation and damage of FICu-IUD on rabbit uterus were milder than that of FCu-IUD. Long-term toxicity test indicated that indomethacin had no obvious influences on rat, such as body weight increase, hematology and biochemical indexes. No distinct abnormality in organ coefficient and pathological tissue examination except uterus was discovered. Oral administration of indomethacin and medicinal silico gel showed no significant reproductive toxicity on rat during teratogenesis sensibility period. It was suggested that FICu-IUD had less toxicity and was safe for clinical use.