CAJ | 학술논문

目的：观察灯笼草的镇痛作用。方法：采用扭体法、电刺激鼠尾-嘶叫法、钾离子透入法和辐射热-缩腿法等行为学指标以及丘脑束旁核神经元对伤害性刺激的放电反应的电生理指标。结果：灯笼草能剂量依赖地提高大鼠电刺激鼠尾-嘶叫法的痛阈，剂量依赖地抑制醋酸引起的小鼠扭体反应，对炎症性痛敏及神经源性痛敏灯笼草也有镇痛作用，灯笼草还能明显抑制丘脑束旁核神经元对伤害性刺激的放电反应。纳洛酮能翻转灯笼草的镇痛作用，反复给予灯笼草能产生耐受，但与吗啡镇痛之间不存在交叉耐受。结论：灯笼草具有镇痛作用，其镇痛作用可能涉及中枢阿片受体。
목적：관찰등롱초적진통작용。방법：채용뉴체법、전자격서미-시규법、갑리자투입법화복사열-축퇴법등행위학지표이급구뇌속방핵신경원대상해성자격적방전반응적전생리지표。결과：등롱초능제량의뢰지제고대서전자격서미-시규법적통역，제량의뢰지억제작산인기적소서뉴체반응，대염증성통민급신경원성통민등롱초야유진통작용，등롱초환능명현억제구뇌속방핵신경원대상해성자격적방전반응。납락동능번전등롱초적진통작용，반복급여등롱초능산생내수，단여마배진통지간불존재교차내수。결론：등롱초구유진통작용，기진통작용가능섭급중추아편수체。
Objective: The experiment was performed to study the analgesic effect of Physalis peruviana L. (PPL.) Methods: The behavioral algesic measurements and the electrophysiological method were used to record extracellularly the nociceptive response of thalamic parafascicular neurons. Results: 1) PPL could dose-dependently raise the pain threshold in tail stimulation-vocalization test in rats and inhibit the writhing reaction induced by acetic acid in mice. PPL could decrease the hyperalgesia in adjuvant arthritis as well was in neuropathic pain in rats. 2) PPL could inhibit the nociceptive response of thalamic parafascicular neurons in rats evoked by sciatic nerve stimulation. 3) The analgesic effect of PPL could be reversed by naloxone; tolerance could develop after repeated administrations of PPL, but no cross-tolerance was observed with morphine analgesia. Conclusion: PPL has a dose-dependent analgesic effect and its analgesic effect might be mediated by central opioid receptor.