中国临床康复
中國臨床康複
중국림상강복
CHINESE JOURNAL OF CLINICAL REHABILITATION
2002年
11期
1705-1706
,共2页
刘瑞峰%刘彦普%周树夏%何黎升%王翔%马全利
劉瑞峰%劉彥普%週樹夏%何黎升%王翔%馬全利
류서봉%류언보%주수하%하려승%왕상%마전리
blast injury%thromboxane A2( TXA2)%prostacyclin I2(PGI2)%radioimmunoassay
Objective To detect the changes of TXA2 and PGI2 levels and discuss the significance of the level and ratio changes during maxillofacial blast injury.Methods The maxillofacial blast injury model was made by standard spherical blast sources produced by NINT.Measure dynamics of blast wave to skin surface.The metabolites of thromboxane A2( TXA2) and prostacyclin(PGI2),TXB2 and 6 keto PGF1α ,in cortex were examined before and 10min,6h,12h,24h,72h,168h after injury by radioimmunoassay.Results The pressure of central skin of blast injury was 335MPa.TXB2 and 6 keto PGF1 levels and the ratio augmented gradually after injury,and reached the peaks [(216.8± 22.5)pg/g and (102.9± 13.5)pg/g respectively] at the 24th hour,and reduced to the normal levels at the 7th day.Conclusions The blast wave can injure the cortex and vessels,thus TXA2 and PGI2 levels and the ratio increase, which aggravate injury of the cerebral cortex.
