中国病理生理杂志
中國病理生理雜誌
중국병리생리잡지
CHINESE JOURNAL OF PATHOPHYSIOLOGY
2001年
11期
1101
,共1页
Cerebral microcirculatory changes in hypovolemic hypotension we re investigat ed in rats with a cardio-pulmonary bypass (CPB) during pulsatile and non-pulsati le flow. The hypovolemic hypotension was induced by reducing the CPB flow-rate. In the non-pulsatile flow, the cardiac beat was stopped using a fibrilator, whi le in the pulsatile flow the cardiac function was retained. The pial microcircul ation was observed and recorded during CPB, using fluorescence videomicroscopy. The arteriolar diameter and red cell velocity were measured based on the recorde d videoimages. The flow-rate was calculated from the measured diameter and veloc ity data. The present results showed that the flow-rate remained almost constant up to 60 mmHg arterial pressure during pulsatile flow. On the other hand, in n on-pulsatile flow, the flow-rate decreased with a decrease in arterial pressure, indicating the impairment of microvascular autoregulation. It was suggested th at pulsatile flow has an advantage over non-pulsatile flow in a view-point of ce rebral microcirculatory changes in hypovolemic hypotension.
Collaborating researchers: Drs. T. Yamakawa, S. Yamaguchi, Y. Ohnishi (National Cardiovascular Center, Osaka,Japan)
Cerebral microcirculatory changes in hypovolemic hypotension we re investigat ed in rats with a cardio-pulmonary bypass (CPB) during pulsatile and non-pulsati le flow. The hypovolemic hypotension was induced by reducing the CPB flow-rate. In the non-pulsatile flow, the cardiac beat was stopped using a fibrilator, whi le in the pulsatile flow the cardiac function was retained. The pial microcircul ation was observed and recorded during CPB, using fluorescence videomicroscopy. The arteriolar diameter and red cell velocity were measured based on the recorde d videoimages. The flow-rate was calculated from the measured diameter and veloc ity data. The present results showed that the flow-rate remained almost constant up to 60 mmHg arterial pressure during pulsatile flow. On the other hand, in n on-pulsatile flow, the flow-rate decreased with a decrease in arterial pressure, indicating the impairment of microvascular autoregulation. It was suggested th at pulsatile flow has an advantage over non-pulsatile flow in a view-point of ce rebral microcirculatory changes in hypovolemic hypotension.
Collaborating researchers: Drs. T. Yamakawa, S. Yamaguchi, Y. Ohnishi (National Cardiovascular Center, Osaka,Japan)
Cerebral microcirculatory changes in hypovolemic hypotension we re investigat ed in rats with a cardio-pulmonary bypass (CPB) during pulsatile and non-pulsati le flow. The hypovolemic hypotension was induced by reducing the CPB flow-rate. In the non-pulsatile flow, the cardiac beat was stopped using a fibrilator, whi le in the pulsatile flow the cardiac function was retained. The pial microcircul ation was observed and recorded during CPB, using fluorescence videomicroscopy. The arteriolar diameter and red cell velocity were measured based on the recorde d videoimages. The flow-rate was calculated from the measured diameter and veloc ity data. The present results showed that the flow-rate remained almost constant up to 60 mmHg arterial pressure during pulsatile flow. On the other hand, in n on-pulsatile flow, the flow-rate decreased with a decrease in arterial pressure, indicating the impairment of microvascular autoregulation. It was suggested th at pulsatile flow has an advantage over non-pulsatile flow in a view-point of ce rebral microcirculatory changes in hypovolemic hypotension.
Collaborating researchers: Drs. T. Yamakawa, S. Yamaguchi, Y. Ohnishi (National Cardiovascular Center, Osaka,Japan)
