CAJ | 학술논문

目的研究系统性红斑狼疮患者(SLE)及健康人外周血Vα24~+Vβ11~+、CD161~+Vα24~+NKT细胞的数量变化.方法采用流式细胞仪检测30例SLE患者和30例健康对照组Va24~+Vβ11~+、CD161~+Vα24~+NKT细胞数量并与临床指标进行相关分析.结果 SLE患者外周血Vα24~+Vβ11~+、CD161~+Vα24~+NKT细胞显著低于正常对照组(P<0.05);SLE患者Vα24~+Vβ11~+、CD161~+Vα24~+NKT细胞与C3,C4呈正相关关系(P<0.01),与SLE疾病活动性指数(SLEDIA)、红细胞沉降率(ESR)呈负相关关系(P<0.05).结论 CD161~+Vα24~+NKT显著低于正常对照组,表明SLE患者血中活化的NKT细胞数量减少,SLE患者外周血Vα24~+Vβ11~+、CD161~+Vα24~+NKT细胞可能参与SLE的发病过程且与病情活动有关.
목적 연구계통성홍반랑창환자(SLE)급건강인외주혈Vα24~+Vβ11~+、CD161~+Vα24~+NKT세포적수량변화.방법 채용류식세포의검측30례SLE환자화30례건강대조조Va24~+Vβ11~+、CD161~+Vα24~+NKT세포수량병여림상지표진행상관분석.결과 SLE환자외주혈Vα24~+Vβ11~+、CD161~+Vα24~+NKT세포현저저우정상대조조(P<0.05);SLE환자Vα24~+Vβ11~+、CD161~+Vα24~+NKT세포여C3,C4정정상관관계(P<0.01),여SLE질병활동성지수(SLEDIA)、홍세포침강솔(ESR)정부상관관계(P<0.05).결론 CD161~+Vα24~+NKT현저저우정상대조조,표명SLE환자혈중활화적NKT세포수량감소,SLE환자외주혈Vα24~+Vβ11~+、CD161~+Vα24~+NKT세포가능삼여SLE적발병과정차여병정활동유관.
Objective To explore the changes of the amount and function of Vα24~+Vβ11~+,CD161~+Vα24~+NKT cells in the peripheral blood of systemic lupus erythematosus (SLE) patients. Methods The amount of Vα24~+Vβ~+,CD16~+Va24~+NKT cells in the peripheral blood of 30 SLE cases and 30 healthy persons were detected by flow cytometry. Results Vα24~+Vβ11~+,CD161~+Vα24~+NKT cells in the peripheral blood of SLE patients were significantly lower than that of normal control (P < 0.05). Vα24~+Vβll~+ and CD161~+Va24~+NKT cells in the pe-ripheral blood of SLE patients positively correlated with the level of the complement (C3,C4) and negatively correlated with SLE disease ac-tivity index (SLEDIA) and ESR. Conclusion Activated NKT cells decreased in the peripheral blood of SLE patients. Vα24~+Vβ11~+ and CD161~+Vα24~+NKT cells might be involved in the pathogenesis and development of SLE.