国际免疫学杂志
國際免疫學雜誌
국제면역학잡지
INTERNATIONAL JOURNAL OF IMMUNOLOGY
2008年
5期
371-374
,共4页
CD4+CD25+调节性T细胞%Ts细胞%系统性红斑狼疮
CD4+CD25+調節性T細胞%Ts細胞%繫統性紅斑狼瘡
CD4+CD25+조절성T세포%Ts세포%계통성홍반랑창
CD4+CD25+Tr%T suppressor cell%SLE
系统性红斑狼疮(SLE)是一种自身免疫系统疾病、可累及全身各个系统、脏器和组织,调节性T细胞(Tr)在其发生发展中发挥了重要的作用.目前所知的Tr具有免疫抑制的作用,包括两个亚群--CD4+Tr(CD4+CD25+Tr、Tr1和Th3细胞)和CD8+Tr(Ts细胞和CD8+CD25+T细胞).全面了解Tr和人类SLE的关系是在此领域发展新的免疫学治疗方法的基础.
繫統性紅斑狼瘡(SLE)是一種自身免疫繫統疾病、可纍及全身各箇繫統、髒器和組織,調節性T細胞(Tr)在其髮生髮展中髮揮瞭重要的作用.目前所知的Tr具有免疫抑製的作用,包括兩箇亞群--CD4+Tr(CD4+CD25+Tr、Tr1和Th3細胞)和CD8+Tr(Ts細胞和CD8+CD25+T細胞).全麵瞭解Tr和人類SLE的關繫是在此領域髮展新的免疫學治療方法的基礎.
계통성홍반랑창(SLE)시일충자신면역계통질병、가루급전신각개계통、장기화조직,조절성T세포(Tr)재기발생발전중발휘료중요적작용.목전소지적Tr구유면역억제적작용,포괄량개아군--CD4+Tr(CD4+CD25+Tr、Tr1화Th3세포)화CD8+Tr(Ts세포화CD8+CD25+T세포).전면료해Tr화인류SLE적관계시재차영역발전신적면역학치료방법적기출.
Systemic lupus erythematosus(SLE) is an autoimmune disease. Almost all the systems could be in-volved. Regulatory T cells play an important role in the occurrence and development of SLE. At present , regu-latory T cells are distinguished as two subpopulations according to their immune suppressive function----CD4+regulatory T cells which include CD4+ CD25+ Tr,Tr1 and Th3, and CD8+ regulatory T cells, which include Tsand CD8+ CD25+ T cells. A full understanding of the relationship between regulatory T cells and human SLE isthe basis for developing novel immunological therapy approach in this area.
