中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2011年
9期
922-924
,共3页
脑钠肽%慢性心房颤动%左心室射血分数
腦鈉肽%慢性心房顫動%左心室射血分數
뇌납태%만성심방전동%좌심실사혈분수
B-type natriuretic peptide%Atrial fibrillation%Left ventricular ejection fraction
目的 探讨影响慢性心房颤动(CAF)患者血浆B型脑钠肽(BNP)水平的相关因素。方法 采用免疫荧光定量测定法检测222例CAF患者[按左心室射血分数(LVEF)高低分为LVEF≥50％组147例,与LVEF＜50％组75例的血浆BNP含量;采用多普勒超声心动图判断LVEF;同时测定患者血糖、总胆固醇、甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、肌酐、尿素氮、肌酸;并记录患者的高血压病史、糖尿病病史、吸烟史。结果 BNP含量在LVEF＜ 50％组较≥50％组明显升高(平均秩,158.00和87.78,Z=-7.705,P＜0.001);Logistic回归分析提示:男性(OR 13.115,95％ CI 3.382 ～50.860,P＜0.001)、高血压病史(OR 3.710,95％ CI 1.104 ～ 12.472,P=0.034)、低总胆固醇(OR 0.397,95％ CI 0.214～0.735,P=0.003)、LVEF(OR 0.791,95％ CI 0.723 ～0.867,P＜0.001)、吸烟史(OR4.660,95％ CI 1.256 ～ 17.281,P=0.021)是BNP升高的独立危险因子。结论 在CAF患者中低左心室射血分数、男性、高血压史、低总胆固醇及吸烟史是血浆BNP水平升高的独立预测因子。
目的 探討影響慢性心房顫動(CAF)患者血漿B型腦鈉肽(BNP)水平的相關因素。方法 採用免疫熒光定量測定法檢測222例CAF患者[按左心室射血分數(LVEF)高低分為LVEF≥50％組147例,與LVEF＜50％組75例的血漿BNP含量;採用多普勒超聲心動圖判斷LVEF;同時測定患者血糖、總膽固醇、甘油三酯、高密度脂蛋白膽固醇、低密度脂蛋白膽固醇、肌酐、尿素氮、肌痠;併記錄患者的高血壓病史、糖尿病病史、吸煙史。結果 BNP含量在LVEF＜ 50％組較≥50％組明顯升高(平均秩,158.00和87.78,Z=-7.705,P＜0.001);Logistic迴歸分析提示:男性(OR 13.115,95％ CI 3.382 ～50.860,P＜0.001)、高血壓病史(OR 3.710,95％ CI 1.104 ～ 12.472,P=0.034)、低總膽固醇(OR 0.397,95％ CI 0.214～0.735,P=0.003)、LVEF(OR 0.791,95％ CI 0.723 ～0.867,P＜0.001)、吸煙史(OR4.660,95％ CI 1.256 ～ 17.281,P=0.021)是BNP升高的獨立危險因子。結論 在CAF患者中低左心室射血分數、男性、高血壓史、低總膽固醇及吸煙史是血漿BNP水平升高的獨立預測因子。
목적 탐토영향만성심방전동(CAF)환자혈장B형뇌납태(BNP)수평적상관인소。방법 채용면역형광정량측정법검측222례CAF환자[안좌심실사혈분수(LVEF)고저분위LVEF≥50％조147례,여LVEF＜50％조75례적혈장BNP함량;채용다보륵초성심동도판단LVEF;동시측정환자혈당、총담고순、감유삼지、고밀도지단백담고순、저밀도지단백담고순、기항、뇨소담、기산;병기록환자적고혈압병사、당뇨병병사、흡연사。결과 BNP함량재LVEF＜ 50％조교≥50％조명현승고(평균질,158.00화87.78,Z=-7.705,P＜0.001);Logistic회귀분석제시:남성(OR 13.115,95％ CI 3.382 ～50.860,P＜0.001)、고혈압병사(OR 3.710,95％ CI 1.104 ～ 12.472,P=0.034)、저총담고순(OR 0.397,95％ CI 0.214～0.735,P=0.003)、LVEF(OR 0.791,95％ CI 0.723 ～0.867,P＜0.001)、흡연사(OR4.660,95％ CI 1.256 ～ 17.281,P=0.021)시BNP승고적독립위험인자。결론 재CAF환자중저좌심실사혈분수、남성、고혈압사、저총담고순급흡연사시혈장BNP수평승고적독립예측인자。
Objective To assess the factors influencing plasma B-type natriuretic peptide(BNP) levels in patients with chronic atrial fibrillation (AF).Methods Clinical and echocardiographic information were detected or collected.Level of plasma BNP were measured through immunofluorescence quantitified method in 222 CAF patients.The patients were divided into two groups according to left ventricular ejection fraction (LVEF) :LVEF ≥50％ (normal group) and LVEF ＜ 50％ (case groups) .LVEF was detected by transthoracic echocardiography.Fasting Blood Glucose, total cholesterol, triglycerides, highdensity lipoprotein cholesterol, low density lipoprotein cholesterol, creatinine, blood urea nitrogen, uric acid, were measured, and history of hypertension, diabetes mellitus and smoking, were recorded.Results Serum levels of BNP in patients of chronic AF with LVEF ＜ 50％ were significantly higher than those with LVEF≥50％ (Mean Rank, 158.00 and 87.78 ,Z =-7.705, P ＜ 0.001) .In multiple logistic regression analysis, male gender (OR: 13.115,95％ CI 3.382 to 50.860,P ＜0.001) ,history of hypertension(OR:3.710,95％ CI 1.104 to 12.472 ,P = 0.034) ,lower TC(OR: 0.397,95％ CI 0.214 to 0.735, P = 0.003) , LVEF(OR :0.791,95 ％ CI 0.723 to 0.867, P ＜ 0.001) , history of smoking(OR: 4.660,95％ CI 1.256 to 17.281, P = 0.021) were significant and independent determinants of BNP elevation.Conclusion Lower LVEF, male gender, history of hypertension and smoking, lower plasma TC are independent predictors of plasma BNP levels in patients with chronic AF.
