CAJ | 학술논문

目的探讨胰腺癌患者中C3、ApoE的表达及其与胰腺癌淋巴转移和临床病理分期的相关性.方法应用免疫组化法检测胰腺癌和正常胰腺组织中C3、ApoE的表达,观察C3、ApoE的阳性表达率及其与胰腺癌淋巴转移和临床病理分期的相关性.结果 C3、ApoE在胰腺癌中的阳性表达率分别为73.68%、86.84%,显著高于正常胰腺组织的阳性表达率42.11%、42.11%(P＜0.01).C3在伴有淋巴转移的胰腺癌中的阳性表达率为56.52%,在无淋巴转移的胰腺癌中的阳性表达率为46.67%(P=0.741),在Ⅰ期胰腺癌中的阳性表达率为57.14%,在Ⅱ～Ⅳ期胰腺癌中的阳性表达率为77.42%(P=0.194);ApoE在伴有淋巴转移的胰腺癌中的阳性表达率为78.26%,显著高于在无淋巴转移的胰腺癌中的阳性表达率(33.33%,P＜0.01),ApoE在Ⅰ期胰腺癌中的阳性表达率为57.14%,显著低于Ⅱ-Ⅳ期胰腺癌中的阳性表达为(93.55%,P＜0.05).结论 C3、ApoE在胰腺癌中均呈高表达;C3与肿瘤有无淋巴转移及临床病理分期无关,可能成为胰腺癌的早期诊断标志物;ApoE与肿瘤的发展密切相关,可能反映胰腺癌的生物学行为.
목적탐토이선암환자중C3、ApoE적표체급기여이선암림파전이화림상병리분기적상관성.방법응용면역조화법검측이선암화정상이선조직중C3、ApoE적표체,관찰C3、ApoE적양성표체솔급기여이선암림파전이화림상병리분기적상관성.결과 C3、ApoE재이선암중적양성표체솔분별위73.68%、86.84%,현저고우정상이선조직적양성표체솔42.11%、42.11%(P＜0.01).C3재반유림파전이적이선암중적양성표체솔위56.52%,재무림파전이적이선암중적양성표체솔위46.67%(P=0.741),재Ⅰ기이선암중적양성표체솔위57.14%,재Ⅱ～Ⅳ기이선암중적양성표체솔위77.42%(P=0.194);ApoE재반유림파전이적이선암중적양성표체솔위78.26%,현저고우재무림파전이적이선암중적양성표체솔(33.33%,P＜0.01),ApoE재Ⅰ기이선암중적양성표체솔위57.14%,현저저우Ⅱ-Ⅳ기이선암중적양성표체위(93.55%,P＜0.05).결론 C3、ApoE재이선암중균정고표체;C3여종류유무림파전이급림상병리분기무관,가능성위이선암적조기진단표지물;ApoE여종류적발전밀절상관,가능반영이선암적생물학행위.
Objective To investigate the association of C3 and ApoE expressions with lymph node metastasis and clinical pathological stage of human pancreatic cancer. Methods Immunohistochemistry was used to detect the expression of C3 and ApoE in pancreatic cancer's tissues and normal pancreatic tissues,and the relevance of C3 and APoE expressions to the metastasis of pancreatic cancer was analyzed. Results The positive rates of C3 and ApoE expressions were 73.68% and 86.84% in pancreatic cancer,significantly higher than those in normal pancreas tissues (42.11% and 42.11%, P＜0.01 ). The positive rate of C3 expressions in pancreatic cancer of lymph node metastasis was 56.52%, in those without lymph node metastasis was 46.67% (P=0.741). The positive rate of C3 expressions in pancreatic cancer of stage Ⅰ was 57.14%, in those of stage Ⅱ - Ⅳ was 77.42% (P=0.194). The positive rate of ApoE expressions in pancreatic cancer of lymph node metastasis was 78.26%, significantly higher than those without lymph node metastasis (33. 33%, P＜0.01). The positive rate of ApoE expressions in pancreatic cancer of stage Ⅰ was 57. 14%, significantly lower than those of stage Ⅱ - Ⅳ (93.55%, P ＜0.05 ). Conclusions C3 and ApoEare all overexpressed in pancreatic cancer. C3 is not related with tumor's lymph node metastasis and clinical stages, may be marker for early diagnosis of pancreatic cancer. ApoE is closely related with tumor' s development, may reflect the biological behavior of pancreatic cancer.