中南大学学报（医学版）
中南大學學報（醫學版）
중남대학학보（의학판）
JOURNAL OF CENTRAL SOUTH UNIVERSITY (MEDICAL SCIENCES)
2009年
9期
846-849
,共4页
大肠早癌%自体荧光%诊断%卟啉Ⅸ
大腸早癌%自體熒光%診斷%卟啉Ⅸ
대장조암%자체형광%진단%계람Ⅸ
colorectal cancer at early stage%autofluorescence%diagnosis%protoporphyrin Ⅸ
目的:研究癌变肠道局部卟啉浓度差异并阐述其在自体荧光光谱诊断中的应用.方法:检测30例大肠癌病人,30例正常人血原卟啉Ⅸ浓度差异,以及60例大肠组织(30例正常;30例异常)原卟啉Ⅸ的含量.结果:癌症病人血液中血原卟啉IX明显高于正常人(P<0.05),大肠癌组织原卟啉IX含量大于大肠正常组织的含量(P<0.05).结论:癌变肠道局部卟啉含量异常升高,是大肠早期癌症自体荧光诊断技术(644.3±5.7)nm处特异荧光峰值的物质基础.
目的:研究癌變腸道跼部卟啉濃度差異併闡述其在自體熒光光譜診斷中的應用.方法:檢測30例大腸癌病人,30例正常人血原卟啉Ⅸ濃度差異,以及60例大腸組織(30例正常;30例異常)原卟啉Ⅸ的含量.結果:癌癥病人血液中血原卟啉IX明顯高于正常人(P<0.05),大腸癌組織原卟啉IX含量大于大腸正常組織的含量(P<0.05).結論:癌變腸道跼部卟啉含量異常升高,是大腸早期癌癥自體熒光診斷技術(644.3±5.7)nm處特異熒光峰值的物質基礎.
목적:연구암변장도국부계람농도차이병천술기재자체형광광보진단중적응용.방법:검측30례대장암병인,30례정상인혈원계람Ⅸ농도차이,이급60례대장조직(30례정상;30례이상)원계람Ⅸ적함량.결과:암증병인혈액중혈원계람IX명현고우정상인(P<0.05),대장암조직원계람IX함량대우대장정상조직적함량(P<0.05).결론:암변장도국부계람함량이상승고,시대장조기암증자체형광진단기술(644.3±5.7)nm처특이형광봉치적물질기출.
Objective To determine the concentration difference in protoporphyrin in cancerous intestine and to discuss its application in laser-induced autofluorescence diagnosis for colorectal cancer at early stage.Methods We detected the concentration of protoporphyrin Ⅸ in 30 patients with colorectal cancer and 30 control patients, as well as that in 60 cases of intestinal tissues (30 control tissues and 30 cancer tissues).Results The concentration of blood protoporphyrin Ⅸ in patients with colorectal cancer was significantly higher than that in the controls (P<0.05). Protoporphyrin Ⅸ concentration in the cancer tissue was significantly higher than that in the control tissues (P<0.05).Conclusion That the concentration of protoporphyrin in cancerous intestine becomes abnormally high may be the material basis for spectrum intensity peak of (644.3±5.7)nm in laser-induced autofluorescence diagnosis for colorectal cancer at early stage.
