CAJ | 학술논문

目的了解系统性红斑狼疮(SLE)患者血清肿瘤标记物CA125的含量变化及其阳性率,探讨CA125与SLE疾病活动度和浆膜腔积液的关系.方法采用化学发光微粒子免疫分析法检测37名SLE患者血清CA125水平,收集患者临床资料和实验室检查结果 ,统计SLE患者CA125阳性率,分析其升高与SLE疾病活动度和浆膜腔积液的关系.结果全部SLE患者血清CA125阳性率为32.4%(12/37),其中活动期患者阳性率为33.3%(8/24),缓解期患者为30.8%(4/13),活动期与缓解期患者间CA125阳性率差异无统计学意义(P>0.05),伴有腹水、胸水的患者CA125的阳性率显著高于不伴腹水、胸水的患者(P<0.05).结论 CA125在SLE患者中有较高的阳性率,其升高可能与浆膜渗出有关而与病情活动无关.
목적 료해계통성홍반랑창(SLE)환자혈청종류표기물CA125적함량변화급기양성솔,탐토CA125여SLE질병활동도화장막강적액적관계.방법 채용화학발광미입자면역분석법검측37명SLE환자혈청CA125수평,수집환자림상자료화실험실검사결과 ,통계SLE환자CA125양성솔,분석기승고여SLE질병활동도화장막강적액적관계.결과 전부SLE환자혈청CA125양성솔위32.4%(12/37),기중활동기환자양성솔위33.3%(8/24),완해기환자위30.8%(4/13),활동기여완해기환자간CA125양성솔차이무통계학의의(P>0.05),반유복수、흉수적환자CA125적양성솔현저고우불반복수、흉수적환자(P<0.05).결론 CA125재SLE환자중유교고적양성솔,기승고가능여장막삼출유관이여병정활동무관.
Objective To investigate the positive rate and concentrations of tumor marker CA125 in sera of patients with systemic lupus erythematosus(SLE),and to analyze the relationship between serum CA125 and SLE disease activity index (SLEDAI),and serous cavity effusion.Methods The tumor marker CA125 in sera of 37 patients with SLE was determined by means of chemiluminescent microparticle immunoassay.The clinical data and results of laboratory examination were collected.The positive rate of serum CA125,and the relationship between serum CA125 and SLEDAI,and serous cavity effusion was statistically analyzed.Results The positive rate of tumor marker CA125 in sera of SLE patients was 32.4% (33.3% in active stage,and 30.8% in remission stage,respectively,P>0.05).The concentration of CA125 in sera of patients with peritoneal effusion or pleural effusion was higher than in those without peritoneal effusion or pleural effusion(P<0.05).Conclusion The positive rate of CA125 in sera is high in SLE patients,which may be related to the serous cavity effusion,but not to the activity of the SLE.