CAJ | 학술논문

目的:探讨血浆同型半胱氨酸(Hcy)浓度与短暂性脑缺血发作(TIA)及传统血管危险因素的关系.方法:采用荧光偏振免疫分析法测定112例TIA患者和62例对照者的血浆Hcy浓度,分析Hcy浓度及相关危险因素.结果:与血浆Hcy浓度＜10.0 μmol/L组相比,血浆Hcy浓度10.0～14.9 μmol/L组(OR=2.450,95% CI 1.091～5.502)和≥15.0 μmol/L组(OR=5.169,95% CI 2.096～12.746)的TIA风险显著增高.将TIA作为应变量,各种血管危险因素(包括Hcy浓度)作为自变量,进行 logistic 回归分析,结果显示,与血浆Hcy浓度＜10.0 μmol/L组相比,血浆Hcy浓度＞10.0 μmol/L组TIA风险显著增高(OR=3.150,95% CI 1.380-7.192).结论:血浆Hcy浓度是TIA的独立危险因素.
목적:탐토혈장동형반광안산(Hcy)농도여단잠성뇌결혈발작(TIA)급전통혈관위험인소적관계.방법:채용형광편진면역분석법측정112례TIA환자화62례대조자적혈장Hcy농도,분석Hcy농도급상관위험인소.결과:여혈장Hcy농도＜10.0 μmol/L조상비,혈장Hcy농도10.0～14.9 μmol/L조(OR=2.450,95% CI 1.091～5.502)화≥15.0 μmol/L조(OR=5.169,95% CI 2.096～12.746)적TIA풍험현저증고.장TIA작위응변량,각충혈관위험인소(포괄Hcy농도)작위자변량,진행 logistic 회귀분석,결과현시,여혈장Hcy농도＜10.0 μmol/L조상비,혈장Hcy농도＞10.0 μmol/L조TIA풍험현저증고(OR=3.150,95% CI 1.380-7.192).결론:혈장Hcy농도시TIA적독립위험인소.
Objective:To investigate the correlation between plasma homocysteine (Hcy) concentration and transient ischemic attack (TIA) and traditional vascular risk factors.Methods:The plasma Hcy concentrations of 112 patients with TIA and 62 controls were measured by fluorescenee polarization immunoassay.Hcy concentrations and related risk factors were analyzed.Results:The risk of TIA was increased significantly in plasma Hcy concentration 10.0 to 14.9 μmol/L group(OR=2.450,95% CI 1.091 to 5.502) and≥15.0 μmol/L group(OR=5.169,95% CI 2.096 to 12.746) compared with plasma Hcy concentration＜10.0 μmol/L group.Using TIA as the dependent wariable,various vascular risk factors (including plasma Hcy concentration) as the independent variable,logistic regression was analyzed.The result showed that the risk of TIA was increased significantly in plasma Hcy concentration＞10.0 μmol/L group compared with plasma Hcy concentration＜10.0 μmol/L group(OR=3.150,95% CI 1.380 to 7.192).Conclusions:Plasma Hcy concentration is an independent risk factor for TIA.