CAJ | 학술논문

目的评价眶周注射曲安奈德联合地塞米松治疗Ⅳ级甲状腺相关性眼病(TAO)患者的效果.方法将90例TAO患者随机分为A、B、C三组,A组眶周注射曲安奈德20 mg联合地塞米松2.5 mg,每4周一次.B组单纯注射曲安奈德20 mg,4周一次;C组口服泼尼松1 mg/kg,每2周减少5 mg,总疗程半年.每4周复查记录视力、眼压、睑裂大小、上睑迟落、眼球突出度、眼球运动度等,随访一年.结果 A组和B组对眼球突出度及眼球运动度的改善作用明显,C疗效差、副作用大,其中A组作用时间最快,第4周有效率为93.3%,眼部症状改善最明显,第4周有效率为80.0%,并发症少.结论眶周注射曲安奈德联合地塞米松能更迅速有效地改善TAO患者眼球突出及眼球运动受限症状,且副作用少,临床上可常规首选应用.
목적 평개광주주사곡안내덕연합지새미송치료Ⅳ급갑상선상관성안병(TAO)환자적효과.방법 장90례TAO환자수궤분위A、B、C삼조,A조광주주사곡안내덕20 mg연합지새미송2.5 mg,매4주일차.B조단순주사곡안내덕20 mg,4주일차;C조구복발니송1 mg/kg,매2주감소5 mg,총료정반년.매4주복사기록시력、안압、검렬대소、상검지락、안구돌출도、안구운동도등,수방일년.결과 A조화B조대안구돌출도급안구운동도적개선작용명현,C료효차、부작용대,기중A조작용시간최쾌,제4주유효솔위93.3%,안부증상개선최명현,제4주유효솔위80.0%,병발증소.결론 광주주사곡안내덕연합지새미송능경신속유효지개선TAO환자안구돌출급안구운동수한증상,차부작용소,림상상가상규수선응용.
Objective To evaluate the effect of triamcinolone orbital injection combined with dexamethasone in treatment of the patients with the grade Ⅳ of thyriod associated ophthalmopathy. Methods NOSPEVS Ⅳ grade of 90 patients were randomly divided into three groups,Group A,orbital injection of triamcinolone combind with dexamethasone, Croup B,simple injection of triamcinolone,Group C,oral prednisone therapy for half a year. To review each record of visual acuity intraocular pressure palpebral fissure size, upper eyelid drop late exophthalmos eye movement and so on every 4 weeks and follow-up for one year. Results Group A and group B of exophthalmos and eye movement improved obviously,however,Group C with poor efficacy and more side effects,and Group A in 3 groups was the fastest with least number of injections and which improved eye symptons significantly with fewer complications. Conclusion Orbital injection of triamcinolone combined with dexamethasone could be more rapid and effective than a simple injection of triamcinolone or oral prednisone to improve symptoms and signs in thyroid ophthalmopathy.