CAJ | 학술논문

目的评价戊巴比妥钠对大鼠复合肌肉动作电位(CMAP)的影响.方法成年SD大鼠10只,雌、雄各半,8周龄,体重240 ～ 260 g.腹腔注射1％戊巴比妥钠40 mg/kg,给药后8min时开始刺激坐骨神经,记录其所支配的腓肠肌的CMAP,刺激强度为0.50、0.55、0.60 V,每个刺激强度重复3次(刺激间隔1 s),波宽0.05 ms,频率10 Hz.每隔5 min重复上述刺激1次,分别为T1、T2、T3、T4、T5、T6、T7、T8、T9、T10.结果与T1时比较,0.50、0.55、0.60 V强度下T3-5时CMAP峰值降低,0.50 V强度下T3-6时CMAP潜伏期延长,0.55、0.60V强度下T4,5时CMAP潜伏期延长(P＜0.05或0.01).结论戊巴比妥钠可抑制大鼠CMAP.
목적 평개무파비타납대대서복합기육동작전위(CMAP)적영향.방법 성년SD대서10지,자、웅각반,8주령,체중240 ～ 260 g.복강주사1％무파비타납40 mg/kg,급약후8min시개시자격좌골신경,기록기소지배적비장기적CMAP,자격강도위0.50、0.55、0.60 V,매개자격강도중복3차(자격간격1 s),파관0.05 ms,빈솔10 Hz.매격5 min중복상술자격1차,분별위T1、T2、T3、T4、T5、T6、T7、T8、T9、T10.결과 여T1시비교,0.50、0.55、0.60 V강도하T3-5시CMAP봉치강저,0.50 V강도하T3-6시CMAP잠복기연장,0.55、0.60V강도하T4,5시CMAP잠복기연장(P＜0.05혹0.01).결론 무파비타납가억제대서CMAP.
Objective To investigate the effects of pentobarbital sodium on compound muscle action potentials (CMAPs) in rats.Methods Ten adult Sprague-Dawley rats (5 males,5 females),aged 8 weeks,weighing 240-260 g,were anesthetized with intraperitoneal 1％ pentobarbital sodium 40 mg/kg.The sciatic nerve was stimulated (intensity 0.50,0.55 and 0.60 V,wave length 0.05 ms,frequency 10 Hz) starting from 8 min after administration.Each intensity was repeated three times at 1 s interval.The stimulation mentioned above was repeated every 5 min.CMAPs from the gastrocnemius muscle were recorded starting from 8 min after administration (T1) and then were recorded every 5 min for 9 times (T2-10),Results The peak value of CMAP was significantly decreased at T3-5 when the intensity was 0.50,0.55 and 0.60 V,and CMAP latency was significantly prolonged at T3-6 when the intensity was 0.50 V,and at T4,5 when the intensity was 0.55 and 0.60 V as compared with those at T1 ( P ＜ 0.05 or 0.01 ).Conclusion Pentobarbital sodium can inhibit CMAPs in rats.