CAJ | 학술논문

分化型甲状腺癌(DTC)在经过手术、放射性碘治疗、甲状腺激素抑制治疗后,仍需终身随诊.目前DTC的日常随诊方法如常规影像学方法、甲状腺球蛋白测定和~(131)I全身显像仍有其不足之处,临床上常常发现一些患者存在不摄碘的失分化病灶,定位这些失分化的病灶,对确定患者的进一步治疗至关重要.肿瘤阳性显像剂~(99)Tc~m-甲氧基异丁基异腈(~(99)Tc~m-MIBI),由于其良好的物理和剂量测量方面的特性,价格便宜,国内外对其在DTC随访中的作用做了大量基础及临床研究.本综述主要从原理、显像方法、显像结果分析、优势介绍~(99)Tc~m-MIBI显像在DTC随访的应用.
분화형갑상선암(DTC)재경과수술、방사성전치료、갑상선격소억제치료후,잉수종신수진.목전DTC적일상수진방법여상규영상학방법、갑상선구단백측정화~(131)I전신현상잉유기불족지처,림상상상상발현일사환자존재불섭전적실분화병조,정위저사실분화적병조,대학정환자적진일보치료지관중요.종류양성현상제~(99)Tc~m-갑양기이정기이정(~(99)Tc~m-MIBI),유우기량호적물리화제량측량방면적특성,개격편의,국내외대기재DTC수방중적작용주료대량기출급림상연구.본종술주요종원리、현상방법、현상결과분석、우세개소~(99)Tc~m-MIBI현상재DTC수방적응용.
Patient suffered from differentiated thyroid carcinoma(DTC)needs lifetime follow-up even after going through the thyroidectomy,postoperative ~(131)I treatment,thyroid stimulating hormone suppressing therapy.There are disadvantages in DTC routine follow-up,such as conventional radiologieal studies,measurement of serum thyrogiobulin and ~(131)I scintigraphy.It is not rare for us to see patients with dedifferentiated metastases which with no radioiodine uptake,and how to locate these dedifferentiated metastases is of great importance for making further treatment plan.Tumor imaging agent ~(99)Tc~m-methoxyisobutylisonitrile(~(99)Tc~m-MIBI)is widely used in the clinical and laboratories research of DTC in domestic and overseas,for its excellent physical and dosimetric characteristics and reasonable price.This review relates the application of ~(99)Tc~m-MIBI imaging in DTC follow-up,and focuses on its imaging mechanism,clinical methods,imaging interpretation,and the advantages.