CAJ | 학술논문

目的探讨胚胎相关基因HOXA13在食管鳞状上皮癌(鳞癌)中的表达及其与临床病理和预后的关系.方法为排除肿瘤TNM分期对生存的影响,全部选择术前均未接受化疗、放疗或其他形式辅助治疗的Ⅱa期(T3N0M0)患者.收集1995年10月至2002年10月间符合上述条件、经手术治疗、具有完整临床病理及随访资料的39 例食管鳞癌患者石蜡包埋组织标本,应用免疫组织化学SP法检测HOXA13蛋白的表达.结果 HOXA13在Ⅱa期食管鳞癌组织中的阳性表达率为61.5%:其表达与患者年龄、性别、肿瘤部位、分化程度无相关(P0.05).Kaplan-Meier生存分析显示,HOXA13阴性表达者术后无病生存期明显长于HOXA13阳性表达者(P<0.05).Cox多因素风险比例模型显示,HOXA13表达是Ⅱa期食管鳞癌患者的独立预后因素(P<0.05).结论 HOXA13表达增高可能是Ⅱa期食管鳞癌患者预后不良的重要指标.
목적 탐토배태상관기인HOXA13재식관린상상피암(린암)중적표체급기여림상병리화예후적관계.방법 위배제종류TNM분기대생존적영향,전부선택술전균미접수화료、방료혹기타형식보조치료적Ⅱa기(T3N0M0)환자.수집1995년10월지2002년10월간부합상술조건、경수술치료、구유완정림상병리급수방자료적39 례식관린암환자석사포매조직표본,응용면역조직화학SP법검측HOXA13단백적표체.결과 HOXA13재Ⅱa기식관린암조직중적양성표체솔위61.5%:기표체여환자년령、성별、종류부위、분화정도무상관(P0.05).Kaplan-Meier생존분석현시,HOXA13음성표체자술후무병생존기명현장우HOXA13양성표체자(P<0.05).Cox다인소풍험비례모형현시,HOXA13표체시Ⅱa기식관린암환자적독립예후인소(P<0.05).결론 HOXA13표체증고가능시Ⅱa기식관린암환자예후불량적중요지표.
Objective To investigate the expression of HOXA13 gene in stage-Ⅱa esophageal squamous cell carcinoma(ESCC), and to evaluate its relationship with clinicopathological characteristics and prognosis. Methods The expression of HOXAI3 was examined by immunohistochemistry(IHC) in specimens from 39 patients with ESCC of stage-Ⅱa, who underwent resection from 1995 to 2002. SPSS software was used to analyze the relationship between HOXA13 expression and clinicopathological characteristics and prognosis of patients. Results The expression of HOXA13 protein was detected in ESCC tissue, and the positive rate was 61.5%. The median survival time of patients without HOXA13 expression(>72 months) was significanfly longer than those with HOXA13 expression (24 months)(P=0.023). Multivariate analysis showed that HOXA13 expression was independent predictor of disease-free survival time of patients with ESCC. Conclusion The expression of HOXA13 can be detected in ESCC and is a negative independent predictor of disease-free survival, which implies that HOXA13 might play a role in ESSC, and may be used as a clinical tumor marker of ESCC.