中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2011年
29期
32-34
,共3页
神经胶质瘤%碱性成纤维生长因子%基质金属蛋白酶-2
神經膠質瘤%堿性成纖維生長因子%基質金屬蛋白酶-2
신경효질류%감성성섬유생장인자%기질금속단백매-2
Glioma%Fibroblast growth factors%Matrix metalloproteinase-2
目的 探讨碱性成纤维细胞生长因子(bFGF)和基质金属蛋白酶2(MMP-2)在脑胶质瘤中的表达及其临床意义.方法 应用免疫组织化学技术,对临床上经过石蜡包埋的56例胶质瘤和9例正常脑组织标本中bFGF和MMP-2的表达水平进行检测,并比较它们之间的相关性.结果 bFGF和MMP-2在高级别胶质瘤(Ⅲ、Ⅳ级)中阳性表达率分别为(41.23±12.35)％和(54.32±7.32)％；在低级别胶质瘤(Ⅰ、Ⅱ级)中阳性表达率分别为(24.78±7.57)％和(21.56±3.85)％；在正常脑组织中阳性表达率分别为(9.51±2.69)％和(7.18±2.12)％.在高、低级别胶质瘤和正常脑组织中bFGF和MMP-2阳性表达率两两比较差异均有统计学意义(P＜0.05),且二者之间表达水平呈正相关(r＝0.71,P＜0.01).结论 bFGF和MMP-2表达水平和胶质瘤的组织学分级密切相关;bFGF和MMP-2的协同作用可能在胶质瘤细胞的侵袭性生长中有重要意义.
目的 探討堿性成纖維細胞生長因子(bFGF)和基質金屬蛋白酶2(MMP-2)在腦膠質瘤中的錶達及其臨床意義.方法 應用免疫組織化學技術,對臨床上經過石蠟包埋的56例膠質瘤和9例正常腦組織標本中bFGF和MMP-2的錶達水平進行檢測,併比較它們之間的相關性.結果 bFGF和MMP-2在高級彆膠質瘤(Ⅲ、Ⅳ級)中暘性錶達率分彆為(41.23±12.35)％和(54.32±7.32)％；在低級彆膠質瘤(Ⅰ、Ⅱ級)中暘性錶達率分彆為(24.78±7.57)％和(21.56±3.85)％；在正常腦組織中暘性錶達率分彆為(9.51±2.69)％和(7.18±2.12)％.在高、低級彆膠質瘤和正常腦組織中bFGF和MMP-2暘性錶達率兩兩比較差異均有統計學意義(P＜0.05),且二者之間錶達水平呈正相關(r＝0.71,P＜0.01).結論 bFGF和MMP-2錶達水平和膠質瘤的組織學分級密切相關;bFGF和MMP-2的協同作用可能在膠質瘤細胞的侵襲性生長中有重要意義.
목적 탐토감성성섬유세포생장인자(bFGF)화기질금속단백매2(MMP-2)재뇌효질류중적표체급기림상의의.방법 응용면역조직화학기술,대림상상경과석사포매적56례효질류화9례정상뇌조직표본중bFGF화MMP-2적표체수평진행검측,병비교타문지간적상관성.결과 bFGF화MMP-2재고급별효질류(Ⅲ、Ⅳ급)중양성표체솔분별위(41.23±12.35)％화(54.32±7.32)％；재저급별효질류(Ⅰ、Ⅱ급)중양성표체솔분별위(24.78±7.57)％화(21.56±3.85)％；재정상뇌조직중양성표체솔분별위(9.51±2.69)％화(7.18±2.12)％.재고、저급별효질류화정상뇌조직중bFGF화MMP-2양성표체솔량량비교차이균유통계학의의(P＜0.05),차이자지간표체수평정정상관(r＝0.71,P＜0.01).결론 bFGF화MMP-2표체수평화효질류적조직학분급밀절상관;bFGF화MMP-2적협동작용가능재효질류세포적침습성생장중유중요의의.
Objective To explore the expression and significance of matrix metalloproteinase-2 (MMP-2) and basic fibroblast growth factor (bFGF) in human glioma.Methods The expression levels of bFGF and MMP-2 in 56 cases of human glioma and 9 cases of normal brain tissue specimen were detected by immunohistochemistry technique.Furthermore,the correlation between the expression of the bFGF and MMP-2 was compared.Results In normal brain tissue,grade Ⅰ,Ⅱ and grade Ⅲ,Ⅳ,the positive expression of bFGF were (9.51 + 2.69)％,(24.78 ±- 7.57 )％,(41.23 ± 12.35 )％,respectively,and MMP-2were (7.18 ± 2.12)％,(21.56 ± 3.85 )％,(54.32 + 7.32)％,respectively.The differences were significant among them (P ＜0.05).bFGF and MMP-2 were positive correlated (r ＝0.71,P ＜0.01).Conclusions There is an intrinsic correlation between the expression of the bFGF and MMP-2 and histological grade of human gliomas.These findings suggest that the synergistic interaction of bFGF and MMP-2 play an important role during the tumor invasion.
