CAJ | 학술논문

目的横断面研究中文版的蒙特利尔认知评估量表(MoCA)在非痴呆性血管性认知障碍汉族老年人筛查中的可行性.方法在103名汉族老年人中区分为非痴呆性血管性认知障碍(VaCIND)患者共64例,正常对照组39例,进行中文版MoCA、中文版简易精神状态量表(MMSE)等检查,研究VaCIND的认知功能特点,使用ROC曲线分析最佳的灵敏度和特异度.结果 2组患者在年龄、性别、教育程度上均差异无显著性(P>0.05),使用中文版MoCA发现VaCIND患者在包括记忆功能、视空间功能、执行功能、注意力、语言功能、定向力得分[分别为(0.44±0.96)分,(2.13±1.40)分,(1.90±1.02)分,(4.61±1.41)分,(4.23±1.40)分,(5.38±1.15)分]均低于正常对照组得分[分别为(2.92±1.42)分,(3.16±1.08)分,(3.32±1.07)分,(5.87±0.41)分,(5.34±0.75)分,(5.79±0.70)分],差异有显著性(P<0.05).MoCA在VaCIND的筛查中较MMSE灵敏,在截断值为24分时对VaCIND的筛查有较高的灵敏度和特异度,分别为0.923和0.906.结论 MoCA是一个简单可靠的VaCIND的筛选工具,并且较MMSE灵敏,需要进一步在大规模人群及不同种族人群中进行研究.
목적 횡단면연구중문판적몽특리이인지평고량표(MoCA)재비치태성혈관성인지장애한족노년인사사중적가행성.방법 재103명한족노년인중구분위비치태성혈관성인지장애(VaCIND)환자공64례,정상대조조39례,진행중문판MoCA、중문판간역정신상태량표(MMSE)등검사,연구VaCIND적인지공능특점,사용ROC곡선분석최가적령민도화특이도.결과 2조환자재년령、성별、교육정도상균차이무현저성(P>0.05),사용중문판MoCA발현VaCIND환자재포괄기억공능、시공간공능、집행공능、주의력、어언공능、정향력득분[분별위(0.44±0.96)분,(2.13±1.40)분,(1.90±1.02)분,(4.61±1.41)분,(4.23±1.40)분,(5.38±1.15)분]균저우정상대조조득분[분별위(2.92±1.42)분,(3.16±1.08)분,(3.32±1.07)분,(5.87±0.41)분,(5.34±0.75)분,(5.79±0.70)분],차이유현저성(P<0.05).MoCA재VaCIND적사사중교MMSE령민,재절단치위24분시대VaCIND적사사유교고적령민도화특이도,분별위0.923화0.906.결론 MoCA시일개간단가고적VaCIND적사선공구,병차교MMSE령민,수요진일보재대규모인군급불동충족인군중진행연구.
Objective To explore feasibility of the Chinese version of MoCA for the detection of vascular cognitive impairment-no dementia (VaCIND) and control in a cross-sectional study. Methods One hundred and three Chinese Han were assessed by the MoCA and MMSE. 64 met criteria for VaCIND and 39 were considered cognitively normal. Sensitivities and specificities were calculated using the recommended cut-off scores,and ROC curve analyses were performed to determine optimal sensitivity and specificity. Results No differences were found between groups on age,gender,education degrees. According to their MoCA scores,cognitive impairments including memory,visuospatial, executive function, attention, language, and orientation sub-scores in VaCIND ((0.44 ± 0.96), (2.13 ±1.40), (1.90 ±1.02), (4.61 ±1.41), (4.23 ±1.40), (5.38 ±1.15)) significantly decreased compared with that in controls((2.92 ± 1.42) ,(3.16 ± 1.08) ,(3.32 ± 1.07) ,(5. 87 ±0.41) ,(5.34 ±0.75), (5.79 ±0. 70)) (P<0. 05). The MMSE scale was insensitive to cognitive impairment as compared with MoCA scale. Using cut-off score of 24,the MoCA exhibited excellent sensitivity (0.923) and specificity (0.906). Conclusion MoCA is a more sensitive instrument than the MMSE for the detection of VaCIND and warrants further investigation regarding its applicability in large group and varying ethnic groups.