中华皮肤科杂志
中華皮膚科雜誌
중화피부과잡지
Chinese Journal of Dermatology
2011年
2期
124-126
,共3页
蒋红伟%田洪青%李中伟%李娜%赵毅%刘殿昌%刘兵%初同胜%刘红%侯建玲%郑荣涛
蔣紅偉%田洪青%李中偉%李娜%趙毅%劉殿昌%劉兵%初同勝%劉紅%侯建玲%鄭榮濤
장홍위%전홍청%리중위%리나%조의%류전창%류병%초동성%류홍%후건령%정영도
梅毒%HLA抗原%等位基因
梅毒%HLA抗原%等位基因
매독%HLA항원%등위기인
Syphilis%HLA antigens%Alleles
目的 探讨山东汉族梅毒患者与HLA-A、B等位基因的相关性.方法 采用PCR-序列特异性寡核苷酸探针杂交(PCR-SSOP)方法对205例山东汉族梅毒患者与5844例山东汉族正常对照的HLA-A、B等位基因表现频率进行检测.结果 梅毒患者组HLA-A*02,B*15、40等位基因频率高于对照组(P值均＜0.01;Pc值均＜0.05),HLA-A*26等位基因频率低于对照组(P=0.003;Pc=0.039),HLA-B*15、40等位基因频率在显性梅毒组高于对照组(P值均＜0.01;Pc值均＜0.05),HLA-A*02、11、29,B*15、40等位基因频率在隐性梅毒组高于对照组(P值均＜0.01;Pc值均＜0.05),HLA-A*30、33等位基因频率在隐性梅毒组低于对照组(P值、Pc值分别为0.002、0.026;0.001、0.013),HLA-A*30等位基因频率在显性梅毒组高于隐性梅毒组(P=0.001;Pc=0.013).结论 HLA-A*02,B*15、40等位基因可能与山东汉族梅毒相关,HLA-A*30可能与山东汉族显性梅毒相关,HLA-A*02、11、29可能与山东汉族隐性梅毒相关.
目的 探討山東漢族梅毒患者與HLA-A、B等位基因的相關性.方法 採用PCR-序列特異性寡覈苷痠探針雜交(PCR-SSOP)方法對205例山東漢族梅毒患者與5844例山東漢族正常對照的HLA-A、B等位基因錶現頻率進行檢測.結果 梅毒患者組HLA-A*02,B*15、40等位基因頻率高于對照組(P值均＜0.01;Pc值均＜0.05),HLA-A*26等位基因頻率低于對照組(P=0.003;Pc=0.039),HLA-B*15、40等位基因頻率在顯性梅毒組高于對照組(P值均＜0.01;Pc值均＜0.05),HLA-A*02、11、29,B*15、40等位基因頻率在隱性梅毒組高于對照組(P值均＜0.01;Pc值均＜0.05),HLA-A*30、33等位基因頻率在隱性梅毒組低于對照組(P值、Pc值分彆為0.002、0.026;0.001、0.013),HLA-A*30等位基因頻率在顯性梅毒組高于隱性梅毒組(P=0.001;Pc=0.013).結論 HLA-A*02,B*15、40等位基因可能與山東漢族梅毒相關,HLA-A*30可能與山東漢族顯性梅毒相關,HLA-A*02、11、29可能與山東漢族隱性梅毒相關.
목적 탐토산동한족매독환자여HLA-A、B등위기인적상관성.방법 채용PCR-서렬특이성과핵감산탐침잡교(PCR-SSOP)방법대205례산동한족매독환자여5844례산동한족정상대조적HLA-A、B등위기인표현빈솔진행검측.결과 매독환자조HLA-A*02,B*15、40등위기인빈솔고우대조조(P치균＜0.01;Pc치균＜0.05),HLA-A*26등위기인빈솔저우대조조(P=0.003;Pc=0.039),HLA-B*15、40등위기인빈솔재현성매독조고우대조조(P치균＜0.01;Pc치균＜0.05),HLA-A*02、11、29,B*15、40등위기인빈솔재은성매독조고우대조조(P치균＜0.01;Pc치균＜0.05),HLA-A*30、33등위기인빈솔재은성매독조저우대조조(P치、Pc치분별위0.002、0.026;0.001、0.013),HLA-A*30등위기인빈솔재현성매독조고우은성매독조(P=0.001;Pc=0.013).결론 HLA-A*02,B*15、40등위기인가능여산동한족매독상관,HLA-A*30가능여산동한족현성매독상관,HLA-A*02、11、29가능여산동한족은성매독상관.
Objective To investigate the association of HLA-A and -B alleles with syphilis in Shandong Han population. Methods The allele frequencies of HLA-A and -B were detected in 205 patients with syphilis and 5844 normal human controls by PCR-sequence specific oligonucleotide probe (PCR-SSOP)method. Results The patients with syphilis showed a higher frequency of HLA-A*02, B*15, B*40 alleles(all P＜0.01, Pc＜0.05) and a lower frequency of HLA-A*26 allele (P= 0.003, Pc = 0.039) than the normal human controls did. There was an increased frequency of HLA-B*15 and B*40 alleles in patients with symptomatic syphilis (both P＜0.01, Pc＜0.05), as well as an elevated frequency of HLA-A*02, 11, 29, B*15 and 40 alleles (all P＜0.01, Pc＜0.05) and a decreased frequency of HLA-A*30 and 33 in patients with asymptomatic syphilis(P=0.002, 0.026, Pc=0.001, 0.013 respectively), compared with the normal human controls. The frequency of HLA-A*30 allele was significantly higher in patients with symptomatic syphilis than in those with asymptomatic syphilis (P = 0.001, Pc = 0.013). Conclusions There seems to be an association between HLA-A*02, B* 15 and B*40 alleles and syphilis, between HLA-A*30 allele and symptomic syphilis, and between HLA-A*02, 11 and 29 alleles and asymptom1atic syphilis, in Shandong Han population.
