CAJ | 학술논문

目的考察果糖氯化钠注射液与92种常用注射剂配伍的稳定性.方法模拟临床常用浓度和配制方法,观察92种常用注射剂与果糖氯化钠注射液配伍后的外观、pH值变化.结果 24 h内,有29种注射剂的pH值在不同的时间点发牛明显改变,13种配伍溶液在不同的时间点发生明显的颜色改变,奥沙利铂配伍溶液于24 h观察到淡黄色针状结晶;乳糖酸红霉素出现了乳化现象.结论头孢西丁钠、头孢唑肟钠、亚胺培南-西司他丁钠、乳糖酸红霉素、替考拉宁、奥沙利铂、肾上腺素7种药物与果糖氯化钠注射液配伍属配伍禁忌,其他85种药物与果糖氯化钠注射液具有较好的相容性,可以作为这些药物的稀释剂或载体应用于临床,但应注意各药的使用时限,部分药物放置时间不宜过长.
목적 고찰과당록화납주사액여92충상용주사제배오적은정성.방법 모의림상상용농도화배제방법,관찰92충상용주사제여과당록화납주사액배오후적외관、pH치변화.결과 24 h내,유29충주사제적pH치재불동적시간점발우명현개변,13충배오용액재불동적시간점발생명현적안색개변,오사리박배오용액우24 h관찰도담황색침상결정;유당산홍매소출현료유화현상.결론 두포서정납、두포서우납、아알배남-서사타정납、유당산홍매소、체고랍저、오사리박、신상선소7충약물여과당록화납주사액배오속배오금기,기타85충약물여과당록화납주사액구유교호적상용성,가이작위저사약물적희석제혹재체응용우림상,단응주의각약적사용시한,부분약물방치시간불의과장.
Objective To investigate the compatible stability of 92 injections used in Fructose and Sodium Chloride Injection. Methods Physical changes and the PH value of the 92 compatibility injections were observed.Results Within 24 hours, the PH value of 29 injections and the colors of 13 compatibility solutions obviously changed. The faint yellow acicular crystallization was observed in the Oxaliplatin compatibility solution after 24 hours. Conclusion The Fructose and Sodium Chloride Injection is incompatible to Cefoxitin, Cefiizoxime, Imipenem Cilastatin Sodium, Erythromycin Lactobionate, Teicoplanin, Oxaliplatin, Adrenalin. But it can be used with other 85 drugs.