CAJ | 학술논문

合成了5个以直链和带支链烷氧基乙酸为载体配基的顺铂类配合物,通过红外光谱、核磁共振氢谱和质谱对配合物进行了表征,并测试了化合物对肺腺癌SPC-A1和胃腺癌BGC823的体外抗肿瘤活性.生物活性测试结果表明,配合物的活性与离去基团有很大关系.配合物4(顺-二(异丙氧基乙酸根)·[(1R,2R)-1,2-反式环己二胺]合铂(Ⅱ))在2个细胞系中均显示最高的体外抗肿瘤活性,甚至超过顺铂.
합성료5개이직련화대지련완양기을산위재체배기적순박류배합물,통과홍외광보、핵자공진경보화질보대배합물진행료표정,병측시료화합물대폐선암SPC-A1화위선암BGC823적체외항종류활성.생물활성측시결과표명,배합물적활성여리거기단유흔대관계.배합물4(순-이(이병양기을산근)·[(1R,2R)-1,2-반식배기이알]합박(Ⅱ))재2개세포계중균현시최고적체외항종류활성,심지초과순박.
Five cisplatin-typed platinum complexes, characteristic of linear and branched alkoxycarboxylates as leaving groups, were synthesized and characterized by infrared, electro-spray ionization MS and 1H NMR spectroscopy. In vitro cytotoxicities of these complexes against SPC-A1 human lung adenocarcinoma and BGC823 human gastric adenocarcinoma cell lines were evaluated. Biological tests reveal that the cytotoxieities of these compounds are highly related to the nature of leaving groups. Complex 4, cis-(trans-1R, 2R-diaminocyclohexane) bis (2-isopropoxyacetate) platinum (Ⅱ), shows the highest cytotoxicity against both cell lines, and its cytotoxicity is higher than that of cisplatin.