中国血吸虫病防治杂志
中國血吸蟲病防治雜誌
중국혈흡충병방치잡지
CHINESE JOURNAL OF SCHISTOSOMIASIS CONTROL
2010年
2期
150-152
,共3页
华海涌%宁安%吴荷珍%高祖禄%张燕%梁幼生
華海湧%寧安%吳荷珍%高祖祿%張燕%樑幼生
화해용%저안%오하진%고조록%장연%량유생
青蒿琥酯%日本血吸虫%再感染
青蒿琥酯%日本血吸蟲%再感染
청호호지%일본혈흡충%재감염
Artesunate%Schistosoma japonicum%Reinfection
目的 观察青蒿琥酯对日本血吸虫再感染的预防效果.方法 志愿者分成3组,服药Ⅰ组服用青蒿琥酯6 mg/kg,每周1次,连服4周;服药Ⅱ组于第1、3周服用青蒿琥酯6mg/kg,每周2次;对照组服用外观与青蒿琥酯相同的安慰剂.3组人员均于实验第4周末用吡喹酮40 mg/kg驱虫处理,实验第8周末采用改良加藤法粪检观察早期治疗效果,第12周末评估预防再感染的效果.结果 早期治疗阶段,服药Ⅰ组、服药Ⅱ组的粪检阳性率与实验前比较差异有统计学意义(P均<0.05);预防再感染阶段,服药Ⅰ组、服药Ⅱ组与实验前相比,粪检阳性率均显著下降(P均<0.05);而对照组粪检阳性率在实验前后无明显差异.结论 青蒿琥酯具有较好的早期治疗和预防血吸虫再感染的效果,剂量6 mg/kg,每周服药1次,连续4周的服药方式较好.
目的 觀察青蒿琥酯對日本血吸蟲再感染的預防效果.方法 誌願者分成3組,服藥Ⅰ組服用青蒿琥酯6 mg/kg,每週1次,連服4週;服藥Ⅱ組于第1、3週服用青蒿琥酯6mg/kg,每週2次;對照組服用外觀與青蒿琥酯相同的安慰劑.3組人員均于實驗第4週末用吡喹酮40 mg/kg驅蟲處理,實驗第8週末採用改良加籐法糞檢觀察早期治療效果,第12週末評估預防再感染的效果.結果 早期治療階段,服藥Ⅰ組、服藥Ⅱ組的糞檢暘性率與實驗前比較差異有統計學意義(P均<0.05);預防再感染階段,服藥Ⅰ組、服藥Ⅱ組與實驗前相比,糞檢暘性率均顯著下降(P均<0.05);而對照組糞檢暘性率在實驗前後無明顯差異.結論 青蒿琥酯具有較好的早期治療和預防血吸蟲再感染的效果,劑量6 mg/kg,每週服藥1次,連續4週的服藥方式較好.
목적 관찰청호호지대일본혈흡충재감염적예방효과.방법 지원자분성3조,복약Ⅰ조복용청호호지6 mg/kg,매주1차,련복4주;복약Ⅱ조우제1、3주복용청호호지6mg/kg,매주2차;대조조복용외관여청호호지상동적안위제.3조인원균우실험제4주말용필규동40 mg/kg구충처리,실험제8주말채용개량가등법분검관찰조기치료효과,제12주말평고예방재감염적효과.결과 조기치료계단,복약Ⅰ조、복약Ⅱ조적분검양성솔여실험전비교차이유통계학의의(P균<0.05);예방재감염계단,복약Ⅰ조、복약Ⅱ조여실험전상비,분검양성솔균현저하강(P균<0.05);이대조조분검양성솔재실험전후무명현차이.결론 청호호지구유교호적조기치료화예방혈흡충재감염적효과,제량6 mg/kg,매주복약1차,련속4주적복약방식교호.
Objective To assess the preventive effect of artesunate against reinfection of Schistosoma japonicum.Methods Volunteers were divided into 3 groups,Medication Group Ⅰ took artesunate 6 mg/kg ,once a week for 4 weeks,Medication Group Ⅱ took artesunate 6 mg/kg in the 1st and 3rd week,twice a week,and a control group was given a placebo.The 3 teams took praziquantel 40 mg/kg on the 4th weekend.The effects of artesunate in early treatment were observed at the 8th weekend,and the preventive effects of artesunate against reinfection were assessed at the 12th weekend.The positive rate of fecal examination was used as the indicator.Results In the stage of early treatment,the positive rates of fecal examination in Medication Group Ⅰ ,Ⅱdecreased significantly compared with the data before the study with all P values less than 0.05 ;in the stage of preventing reinfection,compared with the data before the study,the positive rates of the fecal examination declined significantly in Medication Group Ⅰ,Ⅱ ,with all P values less than 0.05.While in the control group,the positive rates of the fecal examination had no significant changes in the two stages.Conclusions Artesunate has a valid effect against schistosome infections in the early treatment and can prevent residents from reinfection,and the suitable dosage is 6 mg/kg,once a week for 4 weeks.
