中国糖尿病杂志
中國糖尿病雜誌
중국당뇨병잡지
CHINESE JOURNAL OF DIABETES
2010年
10期
742-744
,共3页
徐宽枫%张汝阳%谢海燕%杨涛
徐寬楓%張汝暘%謝海燕%楊濤
서관풍%장여양%사해연%양도
糖尿病,1型%细胞毒性T淋巴细胞相关抗原4%多态性,基因%Meta分析
糖尿病,1型%細胞毒性T淋巴細胞相關抗原4%多態性,基因%Meta分析
당뇨병,1형%세포독성T림파세포상관항원4%다태성,기인%Meta분석
Diabetes mellitus,type 1%Cytotoxic T lymphocyle antigen 4% Polymorphism,gene% Meta-analysis
目的 评价细胞毒性T淋巴细胞相关抗原4(CTLA-4)基因外显子1上49位点A/G多态性与中国人群1型糖尿病(T1DM)的关联性.方法 检索电子期刊数据库,应用RevMan 5.0对入选文献进行Meta分析,并评估发表偏倚.结果 共6篇文献纳入研究,包括970例T1DM患者和1 098名对照.CTLA-4基因49 A/G位点G等位基因与A等位基因OR值为1.82,95%CI为1.59～2.08,P<0.01;基因型(GG+GA)与AA的OR值为2.66,95%CI为1.97～3.60,P<0.01.Begg's检验P=0.261,即所纳入研究未发生发表偏倚.结论 CTLA-4基因49位点G等位基因是中国人群T1DM的遗传危险因素之一.
目的 評價細胞毒性T淋巴細胞相關抗原4(CTLA-4)基因外顯子1上49位點A/G多態性與中國人群1型糖尿病(T1DM)的關聯性.方法 檢索電子期刊數據庫,應用RevMan 5.0對入選文獻進行Meta分析,併評估髮錶偏倚.結果 共6篇文獻納入研究,包括970例T1DM患者和1 098名對照.CTLA-4基因49 A/G位點G等位基因與A等位基因OR值為1.82,95%CI為1.59～2.08,P<0.01;基因型(GG+GA)與AA的OR值為2.66,95%CI為1.97～3.60,P<0.01.Begg's檢驗P=0.261,即所納入研究未髮生髮錶偏倚.結論 CTLA-4基因49位點G等位基因是中國人群T1DM的遺傳危險因素之一.
목적 평개세포독성T림파세포상관항원4(CTLA-4)기인외현자1상49위점A/G다태성여중국인군1형당뇨병(T1DM)적관련성.방법 검색전자기간수거고,응용RevMan 5.0대입선문헌진행Meta분석,병평고발표편의.결과 공6편문헌납입연구,포괄970례T1DM환자화1 098명대조.CTLA-4기인49 A/G위점G등위기인여A등위기인OR치위1.82,95%CI위1.59～2.08,P<0.01;기인형(GG+GA)여AA적OR치위2.66,95%CI위1.97～3.60,P<0.01.Begg's검험P=0.261,즉소납입연구미발생발표편의.결론 CTLA-4기인49위점G등위기인시중국인군T1DM적유전위험인소지일.
Objective To evaluate the relationship between CTLA-4 49A/G gene polymorphisms and T1DM in Chinese population. Methods A comprehensive search of original article on the relationship between CTLA-4 49A/G gene polymorphism and T1DM in Chinese population was done， and the included studies were analyzed by using RevMan 5.0， and Begg’s test， odds ratio， heterogeneity and publication bias test were performed. Results Odds ratios of G allele to T allele and genotypes GG+GA to genotype AA were 1.82 (95% CI: 1.59~2.08， P<0.01) and 2.66 (95% CI: 1.97~3.60，P<0.01)， respectively. Begg’s test revealed no significant bias. Conclusions G allele of CTLA-4 49A/G gene polymorphism confers genetic susceptibility to T1DM in Chinese population.
