CAJ | 학술논문

目的:探讨心肌梗死后晚期血管开通前后血浆内源性硫化氢含量的变化及其意义.方法:选择冠脉造影明确的,未经溶栓的初次心肌梗死患者60例,分为单纯前降支近段闭塞后成功开通组(20例)、单纯右冠近段完全闭塞后成功开通组(20例)和双支病变闭塞后成功开通组(20例),用分光光度法检测各组血管开通前后内源性硫化氢含量.结果:与血管开通前内源性硫化氢水平比较,开通后前降支病变组[ (24.44±3.27)μmol/L比(37.47±2.38)μmol/L]、右冠病变组[(24.48±3.60)μmol/L比(37.22±2.56)μmol/L]、双支病变组[(20.41±2.22)μmol/L比(30.34±2.37)μmol/L]内源性硫化氢水平明显升高(P均＜0.05).结论:心肌梗死后晚期开通血管使血浆内源性硫化氢含量显著增加；对患者的预后是有益的.
목적:탐토심기경사후만기혈관개통전후혈장내원성류화경함량적변화급기의의.방법:선택관맥조영명학적,미경용전적초차심기경사환자60례,분위단순전강지근단폐새후성공개통조(20례)、단순우관근단완전폐새후성공개통조(20례)화쌍지병변폐새후성공개통조(20례),용분광광도법검측각조혈관개통전후내원성류화경함량.결과:여혈관개통전내원성류화경수평비교,개통후전강지병변조[ (24.44±3.27)μmol/L비(37.47±2.38)μmol/L]、우관병변조[(24.48±3.60)μmol/L비(37.22±2.56)μmol/L]、쌍지병변조[(20.41±2.22)μmol/L비(30.34±2.37)μmol/L]내원성류화경수평명현승고(P균＜0.05).결론:심기경사후만기개통혈관사혈장내원성류화경함량현저증가；대환자적예후시유익적.
Abstract:Objective:To explore change of plasma endogenous hydrogen sulfide content before and after late open vasculature in patients with myocardial infarction and its significance.Methods:A total of 60 patients with primary myocardial infarction,who didn′t receive thrombolytic therapy and lesion locations had been confirmed by coronary angiography,were divided into group of successfully open after occlusion in proximal segment of left anterior descending artery (LAD group,n=20),group of successfully open after occlusion in proximal segment of right coronary artery (RCA group,n=20) and group of successfully open after occlusion in proximal segment of both above arteries (LAD+RCA group,n=20).Spectrophotometry method was used to measure concentration of endogenous H2S before and after open vasculature in all groups.Results:Compared with endogenous H2S level before open vasculature,there were significant increase in endogenous H2S level in LAD group [ (24.44±3.27) μmol/L vs.(37.47±2.38) μmol/L],RCA group [ (24.48±3.60) μmol/L vs.(37.22±2.56) μmol/L] and LAD + RCA group [ (20.41±2.22) μmol/L vs.(30.34±2.37) μmol/L] after open vasculature,P＜0.05 all.Conclusion:Concentration of endogenous hydrogen sulfide significantly increases after open vasculature in patients with myocardial infarction; it may be beneficial for prognosis of patients.