CAJ | 학술논문

带状疱疹后神经痛是指带状疱疹皮损消退4周后,神经痛仍然持续存在.带状疱疹后神经痛的发病率与年龄密切相关,主要表现为烧灼样痛、电击样痛、刀割样痛、浅感觉异常等,其主要从睡眠、情绪等方面影响着患者的生活质量.新药普瑞巴林是一种抑制性神经递质γ-氨基丁酸的结构衍生物,通过与α2-δ配体结合,变构α2-δ亚基,调节钙通道接近正常的生理水平,从而达到治疗神经痛的目的.普瑞巴林的维持用药时间4～12周,可变剂量和固定剂量在缓解带状疱疹后神经痛及改善患者生活质量方面均具有显著疗效.具有长期用药不良反应轻微、药物的相互作用少等.
대상포진후신경통시지대상포진피손소퇴4주후,신경통잉연지속존재.대상포진후신경통적발병솔여년령밀절상관,주요표현위소작양통、전격양통、도할양통、천감각이상등,기주요종수면、정서등방면영향착환자적생활질량.신약보서파림시일충억제성신경체질γ-안기정산적결구연생물,통과여α2-δ배체결합,변구α2-δ아기,조절개통도접근정상적생리수평,종이체도치료신경통적목적.보서파림적유지용약시간4～12주,가변제량화고정제량재완해대상포진후신경통급개선환자생활질량방면균구유현저료효.구유장기용약불량반응경미、약물적상호작용소등.
Postherpetic neuralgia (PHN) refers to a painful condition that persists for 4 weeks after the rash of shingles has gone away.The incidence of PHN is age-related.PHN may feel like a burning pain,electric shock,knifelike pain,paresthesia,etc.It often affects the quality of life of patients from the aspects of sleep,emotion,and so on.Pregabalin,a new type of gamma-aminobutyric acid receptor agonist,can control PHN via binding to the calcium channel alpha 2-delta type 1 subunit in the central nervous system,altering the conformation of alpha 2-delta subunit,and thereby restoring the calcium channel to nearly normal level.Both flexible- and fixed-dose of pregabalin for 4 to 12 weeks have been reported to be markedly effective for the control of PHN and improvement of patients' quality of life.Long-term pregabalin exhibits good tolerability and few drug interactions.