中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2009年
4期
599-600
,共2页
糖尿病,2型%糖尿病血管病变%血糖
糖尿病,2型%糖尿病血管病變%血糖
당뇨병,2형%당뇨병혈관병변%혈당
Diabetes mellitus,Type 2%Diabetic Angiopathies%Blood geucose
目的 探讨2型糖尿病患者波动性高血糖状态对糖尿病慢性并发症的影响.方法 169例糖化血红蛋白(HbA1C)相近2型糖尿病患者分为两组:慢性持续性高血糖组(Ⅰ组,78例)、慢性波动性高血糖组(Ⅱ组,91例).测定患者的空腹血糖(FBG)、餐后2 h血糖(2hPG)、糖化血红蛋白(HbA1c)、胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL)、低密度脂蛋白胆固醇(LDL)、空腹胰岛素(FINS)、餐后2 h胰岛素(2MNS)、空腹C肽、餐后2 h C肽、24 h尿白蛋白定量(UAER),并分析其糖尿病慢性并发症的发生情况.结果 Ⅱ组2hPG显著高于Ⅰ组(P<0.01),餐后2 h胰岛素与餐后2 h C肽水平显著低于Ⅰ组(P<0.01).Ⅱ组糖尿病慢性并发症发生率显著高于Ⅰ组(P<0.01).结论 2型糖尿病在波动性高血糖状态下慢性并发症明显增加.
目的 探討2型糖尿病患者波動性高血糖狀態對糖尿病慢性併髮癥的影響.方法 169例糖化血紅蛋白(HbA1C)相近2型糖尿病患者分為兩組:慢性持續性高血糖組(Ⅰ組,78例)、慢性波動性高血糖組(Ⅱ組,91例).測定患者的空腹血糖(FBG)、餐後2 h血糖(2hPG)、糖化血紅蛋白(HbA1c)、膽固醇(TC)、甘油三酯(TG)、高密度脂蛋白膽固醇(HDL)、低密度脂蛋白膽固醇(LDL)、空腹胰島素(FINS)、餐後2 h胰島素(2MNS)、空腹C肽、餐後2 h C肽、24 h尿白蛋白定量(UAER),併分析其糖尿病慢性併髮癥的髮生情況.結果 Ⅱ組2hPG顯著高于Ⅰ組(P<0.01),餐後2 h胰島素與餐後2 h C肽水平顯著低于Ⅰ組(P<0.01).Ⅱ組糖尿病慢性併髮癥髮生率顯著高于Ⅰ組(P<0.01).結論 2型糖尿病在波動性高血糖狀態下慢性併髮癥明顯增加.
목적 탐토2형당뇨병환자파동성고혈당상태대당뇨병만성병발증적영향.방법 169례당화혈홍단백(HbA1C)상근2형당뇨병환자분위량조:만성지속성고혈당조(Ⅰ조,78례)、만성파동성고혈당조(Ⅱ조,91례).측정환자적공복혈당(FBG)、찬후2 h혈당(2hPG)、당화혈홍단백(HbA1c)、담고순(TC)、감유삼지(TG)、고밀도지단백담고순(HDL)、저밀도지단백담고순(LDL)、공복이도소(FINS)、찬후2 h이도소(2MNS)、공복C태、찬후2 h C태、24 h뇨백단백정량(UAER),병분석기당뇨병만성병발증적발생정황.결과 Ⅱ조2hPG현저고우Ⅰ조(P<0.01),찬후2 h이도소여찬후2 h C태수평현저저우Ⅰ조(P<0.01).Ⅱ조당뇨병만성병발증발생솔현저고우Ⅰ조(P<0.01).결론 2형당뇨병재파동성고혈당상태하만성병발증명현증가.
Objective To explore the relation between glucose fluctuation state and diabetic chronic compli-cations in type 2 diabetes mellitus. Methods 169 cases with type 2 diabetes mellitus were divided into two groups: 78 cases with constant high glucose(group Ⅰ) and 91 cases with glucose fluctuation state( group Ⅱ ). The clinical data such as fasting plasma glucose(FBG) ,fasting blood insulin(FINS) ,fasting blood C peptide,2 hours postprandial plasma glucose (2hPG) ,2 hours postprandial blood insuline (2hINS) ,2 hours postprandial blood C peptide, glycosy-lated hemoglobin A1c (HbA1c), and blood pressure (BP), body mass index ( BMI ), urinary albumin excretion rote (UAER) ,triglyeeride(TG) ,total cholesterol(TC) ,high density lipoprotein cholesterol(HDL-C) ,low density lipopro-tein cholesterol(LDL-C) were measured. Results 2hPG in group Ⅱ was much higher than that in group Ⅰ (P<0.01) ,but 2 hours postprandial blood insuline and 2 hours postprandial blood C peptide in group Ⅱ were much lower than those in group Ⅰ (P<0.01). The incidence of diabetic chronic complications was higher in group Ⅱ compared with that in group Ⅰ (P<0.01). Conclusion These findings suggest that glucose fluctuation state with type 2 dia-betes mellitus had increased diabetic chronic complications.
