中国小儿急救医学
中國小兒急救醫學
중국소인급구의학
CHINESE PEDIATRIC EMERGENCY MEDICINE
2011年
5期
406-407
,共2页
黄建宝%张新萍%罗海燕%祝益民%赵祥文
黃建寶%張新萍%囉海燕%祝益民%趙祥文
황건보%장신평%라해연%축익민%조상문
细胞因子%炎症介质%抗炎症介质%白细胞介素-6%白细胞介素-10%肿瘤坏死因子-α%脓毒症%儿童
細胞因子%炎癥介質%抗炎癥介質%白細胞介素-6%白細胞介素-10%腫瘤壞死因子-α%膿毒癥%兒童
세포인자%염증개질%항염증개질%백세포개소-6%백세포개소-10%종류배사인자-α%농독증%인동
Cytokines%Inflammatory Mediators%Anti-inflammatory Media%Interleukin-6%Interleukin-10%tumor necrosis factor-α%Sepsis%Children
目的 探讨脓毒症患儿血清白细胞介素(interleukin,IL)-6、IL-10及肿瘤坏死因子(tumor necrosis factor,TNF)-α的浓度与脓毒症预后的相关性.方法 对象为PICU收治的57例脓毒症患儿,其中存活44例(脓毒症存活组),死亡13例(脓毒症死亡组).另有65例非脓毒症患儿为对照(非脓毒症组).分别比较各组患儿危重症评分、脏器损害数目及血清中IL-6、IL-10、TNF-α、IL-6/IL-10、TNF-α/IL-10的水平.结果与非脓毒症组及脓毒症存活组比较,脓毒症死亡组患儿脏器损害数目多,危重症评分低(P＜0.05)；血清炎症细胞因子IL-6的表达增加(P＜0.05),血清抗炎症细胞因子IL-10水平明显升高(P＜0.05),TNF-α/IL-10比值明显降低(P＜0.05),但脓毒症存活组与非脓毒症组比较差异无统计学意义(P＞0.05).3组血清TNF-α浓度及IL-6/IL-10比值差异无统计学意义(P＞0.05).结论脓毒症患儿IL-6、IL-10浓度越高及TNF-α/IL-10比值越小,预后越差.
目的 探討膿毒癥患兒血清白細胞介素(interleukin,IL)-6、IL-10及腫瘤壞死因子(tumor necrosis factor,TNF)-α的濃度與膿毒癥預後的相關性.方法 對象為PICU收治的57例膿毒癥患兒,其中存活44例(膿毒癥存活組),死亡13例(膿毒癥死亡組).另有65例非膿毒癥患兒為對照(非膿毒癥組).分彆比較各組患兒危重癥評分、髒器損害數目及血清中IL-6、IL-10、TNF-α、IL-6/IL-10、TNF-α/IL-10的水平.結果與非膿毒癥組及膿毒癥存活組比較,膿毒癥死亡組患兒髒器損害數目多,危重癥評分低(P＜0.05)；血清炎癥細胞因子IL-6的錶達增加(P＜0.05),血清抗炎癥細胞因子IL-10水平明顯升高(P＜0.05),TNF-α/IL-10比值明顯降低(P＜0.05),但膿毒癥存活組與非膿毒癥組比較差異無統計學意義(P＞0.05).3組血清TNF-α濃度及IL-6/IL-10比值差異無統計學意義(P＞0.05).結論膿毒癥患兒IL-6、IL-10濃度越高及TNF-α/IL-10比值越小,預後越差.
목적 탐토농독증환인혈청백세포개소(interleukin,IL)-6、IL-10급종류배사인자(tumor necrosis factor,TNF)-α적농도여농독증예후적상관성.방법 대상위PICU수치적57례농독증환인,기중존활44례(농독증존활조),사망13례(농독증사망조).령유65례비농독증환인위대조(비농독증조).분별비교각조환인위중증평분、장기손해수목급혈청중IL-6、IL-10、TNF-α、IL-6/IL-10、TNF-α/IL-10적수평.결과여비농독증조급농독증존활조비교,농독증사망조환인장기손해수목다,위중증평분저(P＜0.05)；혈청염증세포인자IL-6적표체증가(P＜0.05),혈청항염증세포인자IL-10수평명현승고(P＜0.05),TNF-α/IL-10비치명현강저(P＜0.05),단농독증존활조여비농독증조비교차이무통계학의의(P＞0.05).3조혈청TNF-α농도급IL-6/IL-10비치차이무통계학의의(P＞0.05).결론농독증환인IL-6、IL-10농도월고급TNF-α/IL-10비치월소,예후월차.
Objective To investigate the correlation of serum concentrations of interleukin(IL)-6,IL-10 and tumor necrosis factor(TNF)-α and the prognosis of sepsis in children.Methods Fifty-seven septic patients in PICU were enrolled in the study,of whom 44 patients survived(sepsis survival group),13 patients died(sepsis dead group).Another 65 cases of non-sepsis patients served as control(non-sepsis group).The critical illness score,the number of damaged organs,and serum levels of IL-6,IL-10,TNF-α,IL-6/IL-10,TNF-α/IL-10 in each group were compared.Results The critical illness score was decreased and the number of damaged organs was more in sepsis dead group than those in non-sepsis group and sepsis survival group.Compared with non-sepsis group and sepsis survival group,the expression of IL-6 and IL-10 increased,TFN-α/IL-10 ratio significantly decreased in sepsis dead group(P ＜ 0.05),but the difference between the sepsis survival group and non-sepsis group was not statistically significant(P ＞ 0.05).The serum levels of TNF-α and IL-6/IL-10 ratio showed no significant difference among three groups(P ＞ 0.05).Conclusion In sepsis patients,the serum concentrations of IL-6,IL-10 are higher and the TNF-α/IL-10 ratio is smaller,the prognosis is worse.
