清华大学学报(英文版)
清華大學學報(英文版)
청화대학학보(영문판)
TSINGHUA SCIENCE AND TECHNOLOGY
2003年
4期
402-406
,共5页
knowledge-based contact potential%protein-protein recognition%semi-energetic scoring function
Protein-protein recognition is an important step in biological processes, which still largely remains elusive.The inter-residue contact potential, CPij, describes the propensity of contact between two types of residue.In this study, several different CPij variants were examined with the objective of discriminating the binding potential of surface pairs.Using solvent mediated inter-molecule contact potential (SM-IMCPij), an evaluation model was deduced and tested.Using the evaluation model it was found that the SM-IMCPij gives a better performance than either residue mediated IMCPij(RM-IMCPij) or folding-residue contact potential (FCPij).The results suggest that the evaluation model provides a fast, effective, and discriminative method for the evaluation of proposed binding interfaces.
