CAJ | 학술논문

目的: 探讨环氧化酶-2(COX-2)-765G>C的单核昔酸多态性与回族人群胃癌易感性的关系.方法: 以PCR-限制性片段长度多态性方法对回族人群中胃癌组( n = 100)、癌前病变组( n =102)和正常对照组( n = 105)进行基因分型. 使用ELISA法检测H pylori感染.结果: COX-2-765GC+CC在胃癌组显著增高( P = 0.021). 交互作用分析显示: 食腌菜的-765GC+CC携带者患胃癌的风险是不食腌菜的-765GG携带者的5.038倍( P = 0.000);H pylori感染阳性的-765GC+CC携带者患胃癌的风险是H pylori感染阴性-765 GG携带者的3.520倍( P = 0.002).结论: COX-2-765G>C和中国甘肃地区回族人群胃癌易感性增高相关. -765 GC+CC分别与食腌菜、H pylori感染在胃癌的发病风险中存在着加乘交互效应.
목적: 탐토배양화매-2(COX-2)-765G>C적단핵석산다태성여회족인군위암역감성적관계.방법: 이PCR-한제성편단장도다태성방법대회족인군중위암조( n = 100)、암전병변조( n =102)화정상대조조( n = 105)진행기인분형. 사용ELISA법검측H pylori감염.결과: COX-2-765GC+CC재위암조현저증고( P = 0.021). 교호작용분석현시: 식업채적-765GC+CC휴대자환위암적풍험시불식업채적-765GG휴대자적5.038배( P = 0.000);H pylori감염양성적-765GC+CC휴대자환위암적풍험시H pylori감염음성-765 GG휴대자적3.520배( P = 0.002).결론: COX-2-765G>C화중국감숙지구회족인군위암역감성증고상관. -765 GC+CC분별여식업채、H pylori감염재위암적발병풍험중존재착가승교호효응.
AIM: To explore the correlation between nucleotide polymorphisms in cyclooxygenase-2 (COX-2)-765G>C and the susceptibility to gastric cancer in Hui ethnic group.METHODS: All investigated objects were divided into 3 groups: 100 gastric cancer patients,102 precancerous lesion patients and 105 control subjects were enrolled. Polymerase chain reaction-restricted fragments length polymorphism (PCR-RFLP) method was used to detect genotypes of -765G>C polymorphisms. ELASA method was used to identify IgGto H pylori. The results were analyzed using SPSS13.0.RESULTS: COX-2 -765GC + CC genotypes were overrepresented in the gastric cancer group than in controls (P = 0.021). Interaction analysis showed that -765 GC+CC carriers who ate pickle vegetables a lot had a 5.038-fold increased risk for developing gastric cancer compared with -765GG carriers with not eating pickle vegetables (P = 0.000);-765GC + CC carriers with positive H pylori infection had a 3.520-fold increased risk for developing gastric cancer compared with -765GG carriers with negative H pylori infection (P = 0.002).CONCLUSION: COX-2-765G>C contributes to an increased susceptibility to gastric cancer in Hui ethnic group in Linxia City,Gansu Province. Multiplicative interactions exist between -765GC + CC and eating pickle vegetables,-765GC + CC and H pylori infection in the risk of developing gastric cancer.