CAJ | 학술논문

报道了一种新颖的带吩噻嗪基团8-羟基喹啉衍生物抗氧化剂,该化合物通过5-氯甲基-8-羟基喹啉与吩噻嗪在有机碱三乙胺存在下的反应而制备,并通过核磁共振谱、红外光谱和元素分析进行了表征,其羟基扫描活性通过可见-紫外吸收光谱进行了测定,抗氧化活性用2,2-二苯基-1-苦基肼(DPPH)模型系统进行了测定.与叔丁对氧酚相比,5-吩噻嗪甲基-8-羟基喹啉表现出了很高的抗氧化活性,当其质量浓度分别为0.2,0.5,0.8和1.0 mg/mL时,相应的最大自由基清除率分别37.55%,76.16%,83.94%和84.04%.
보도료일충신영적대분새진기단8-간기규람연생물항양화제,해화합물통과5-록갑기-8-간기규람여분새진재유궤감삼을알존재하적반응이제비,병통과핵자공진보、홍외광보화원소분석진행료표정,기간기소묘활성통과가견-자외흡수광보진행료측정,항양화활성용2,2-이분기-1-고기정(DPPH)모형계통진행료측정.여숙정대양분상비,5-분새진갑기-8-간기규람표현출료흔고적항양화활성,당기질량농도분별위0.2,0.5,0.8화1.0 mg/mL시,상응적최대자유기청제솔분별37.55%,76.16%,83.94%화84.04%.
A novel anfioxidant 8-hydroxyquinoline derivative with phenothiazine group was reported.5-Phenothiazinylmethylene-8-hydroxyquinoline(PMHQ) was synthesized from reaction of 5-chlommethyl-8-qumotinol hy&oehloride with phenothiazine in the presence of organic base triethylamine and characterized by NMR and IR spectrocopies along with microanalyses.The hyamxyl radical scavenging activities were tested by UV-Vis spectrophotometry.The anfioxidant activities were detected with 2,2-diphenyl-1-pierylhydrazyl(DPPH)model system.Compared with butylated hydroxytoluene (BHT),PMHQ showed relatively hish oxidation resistance.When the nlass concentrations Were 0.2,0.5,0.8 and 1.0 mg/mL,the hishest free radical scavenging rates of PMHQ were 37.55%,76.16%,83.94%and 84.04%,respectively.