CAJ | 학술논문

目的探讨环氧化酶-2(COX-2)启动子区遗传变异与食管癌发病风险的关系,并评价幽门螺杆菌(Hp)感染对其相互作用的影响.方法以PCR-限制性片断长度多态性方法在119例食管癌患者和238例健康对照中进行基因分型.以Logistic回归计算比值比(OR)和95%可信区间(CI).结果 COX-2启动子区-1195 G>A遗传变异和食管癌发病风险相关.与1195GG基因型携带者相比,1195GA基因型和1195AA基因型罹患食管癌的发病风险增高,其OR(95%CI)值分别为2.69(1.46～5.14)和2.30(1.23～4.89).而且这种相关关系仅存在于Hp感染阳性的个体中,其OR(95%CI)值为2.74(1.35～5.96).结论 COX-2启动子区遗传变异对食管癌发病风险的影响和Hp感染的状态有关.
목적 탐토배양화매-2(COX-2)계동자구유전변이여식관암발병풍험적관계,병평개유문라간균(Hp)감염대기상호작용적영향.방법 이PCR-한제성편단장도다태성방법 재119례식관암환자화238례건강대조중진행기인분형.이Logistic회귀계산비치비(OR)화95%가신구간(CI).결과 COX-2계동자구-1195 G>A유전변이화식관암발병풍험상관.여1195GG기인형휴대자상비,1195GA기인형화1195AA기인형리환식관암적발병풍험증고,기OR(95%CI)치분별위2.69(1.46～5.14)화2.30(1.23～4.89).이차저충상관관계부존재우Hp감염양성적개체중,기OR(95%CI)치위2.74(1.35～5.96).결론 COX-2계동자구유전변이대식관암발병풍험적영향화Hp감염적상태유관.
Objective To evaluate the association of COX2 genetic variants with the risk of esophageal cancer and the interaction of COX2 genetic variants with Hp infection. Methods A total of 119 patients with esophageal cancer and 238 frequency-matched controls were genotyped by polymerase chain reaction-restriction fragment length polymorphism method. Odds ratios (OR) and 95% confidence intervals ( CI) were estimated by logistic regression. Results Case-control analysis showed an increased risk of developing esophageal cancer for 1195 GA(OR =2.69,95% CI= 1. 46-5. 14) and 1195AA ( OR = 2. 30,95% CI = 1.23-4. 89) genotype carriers,respectively, compared with non 1195 GG carriers. When stratified by Hp status, the significantly increased risk of esophageal cancer was found among Hp carrier with OR (95%CI) =2.74 (1.35-5.96) ,but not among Hp non-carriers. Conclusion Genetic polymorphism in COX2 promoter region may play an important role in esophageal cancer by Hp infection.